Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a rare and highly aggressive malignancy. In this study, we identified the presence of gene deletion and missense mutation leading to inactivation or underexpression of liver kinase B1 (LKB1) tumor suppressor and excluded the involvement of LKB1 gene hypermeth...

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Detalles Bibliográficos
Autores principales: Wang, Jinghan, Zhang, Keqiang, Wang, Jinhui, Wu, Xiwei, Liu, Xiyong, Li, Bin, Zhu, Yan, Yu, Yong, Cheng, Qingbao, Hu, Zhenli, Guo, Chao, Hu, Shuya, Mu, Bing, Tsai, Chun-Hao, Li, Jie, Smith, Lynne, Yang, Lu, Liu, Qi, Chu, Peiguo, Chang, Vincent, Zhang, Baihe, Wu, Mengchao, Jiang, Xiaoqing, Yen, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662463/
https://www.ncbi.nlm.nih.gov/pubmed/26056085

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