MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism

MUC16, a transmembrane mucin, facilitates pancreatic adenocarcinoma progression and metastasis. In the current studies, we observed that MUC16 knockdown pancreatic cancer cells exhibit reduced glucose uptake and lactate secretion along with reduced migration and invasion potential, which can be rest...

Descripción completa

Detalles Bibliográficos
Autores principales: Shukla, Surendra K., Gunda, Venugopal, Abrego, Jaime, Haridas, Dhanya, Mishra, Anusha, Souchek, Joshua, Chaika, Nina V., Yu, Fang, Sasson, Aaron R., Lazenby, Audrey J., Batra, Surinder K., Singh, Pankaj K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662479/
https://www.ncbi.nlm.nih.gov/pubmed/26046375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662479/
https://www.ncbi.nlm.nih.gov/pubmed/26046375

Ejemplares similares