Foreign DNA capture during CRISPR–Cas adaptive immunity

Bacteria and archaea generate adaptive immunity against phages and plasmids by integrating foreign DNA of specific 30–40 base pair (bp) lengths into clustered regularly interspaced short palindromic repeats (CRISPR) loci as spacer segments(1–6). The universally conserved Cas1–Cas2 integrase complex...

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Detalles Bibliográficos
Autores principales: Nuñez, James K., Harrington, Lucas B., Kranzusch, Philip J., Engelman, Alan N., Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662619/
https://www.ncbi.nlm.nih.gov/pubmed/26503043
http://dx.doi.org/10.1038/nature15760

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