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Association of Helicobacter pylori antibodies and severity of migraine attack
Background: Recent studies have shown a positive correlation between Helicobacter pylori infection and migraine headache. The aim of this study was to evaluate the role of H. pylori infection in migraine headache with (MA) and without aura (MO). Methods: This is a case-control study containing infor...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tehran University of Medical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662684/ https://www.ncbi.nlm.nih.gov/pubmed/26622976 |
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author | Ansari, Behnaz Basiri, Keivan Meamar, Rokhsareh Chitsaz, Ahmad Nematollahi, Shahrzad |
author_facet | Ansari, Behnaz Basiri, Keivan Meamar, Rokhsareh Chitsaz, Ahmad Nematollahi, Shahrzad |
author_sort | Ansari, Behnaz |
collection | PubMed |
description | Background: Recent studies have shown a positive correlation between Helicobacter pylori infection and migraine headache. The aim of this study was to evaluate the role of H. pylori infection in migraine headache with (MA) and without aura (MO). Methods: This is a case-control study containing information on 84 patients (including MA, MO) and 49 healthy individuals. The enzyme-linked immunosorbent assay (ELISA) test was used to measure immunoglobulin G (IgG,) immunoglobulin M (IgM) titer in two groups. Headache severity was evaluated according to Headache Impact Test (HIT6) questionnaire. Results: Mean ± SD of IgM antibody in Migrainous patients 26.3 (23.1) showed significantly difference with control group 17.5 (11.2) (P = 0.004). In addition, the mean ± SD HIT6 in Migrainous patients differed significantly between MA and MO groups 65.5 (4.7), 54.9 (5.3) respectively, P < 0.001). The only significant correlation was found for IgG antibody and HIT6 in MA patients (r = 0.407, P = 0.011) and MO group (r = 0.499, P = 0.002). The risk of migraine occurrence in patients did not significantly associate with the level of IgG and IgM antibodies. Conclusion: The results give a hope that definite treatment and eradication of this bacterium could be a cure or to reduce the severity and course of migraine headaches. |
format | Online Article Text |
id | pubmed-4662684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Tehran University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-46626842015-11-30 Association of Helicobacter pylori antibodies and severity of migraine attack Ansari, Behnaz Basiri, Keivan Meamar, Rokhsareh Chitsaz, Ahmad Nematollahi, Shahrzad Iran J Neurol Original Article Background: Recent studies have shown a positive correlation between Helicobacter pylori infection and migraine headache. The aim of this study was to evaluate the role of H. pylori infection in migraine headache with (MA) and without aura (MO). Methods: This is a case-control study containing information on 84 patients (including MA, MO) and 49 healthy individuals. The enzyme-linked immunosorbent assay (ELISA) test was used to measure immunoglobulin G (IgG,) immunoglobulin M (IgM) titer in two groups. Headache severity was evaluated according to Headache Impact Test (HIT6) questionnaire. Results: Mean ± SD of IgM antibody in Migrainous patients 26.3 (23.1) showed significantly difference with control group 17.5 (11.2) (P = 0.004). In addition, the mean ± SD HIT6 in Migrainous patients differed significantly between MA and MO groups 65.5 (4.7), 54.9 (5.3) respectively, P < 0.001). The only significant correlation was found for IgG antibody and HIT6 in MA patients (r = 0.407, P = 0.011) and MO group (r = 0.499, P = 0.002). The risk of migraine occurrence in patients did not significantly associate with the level of IgG and IgM antibodies. Conclusion: The results give a hope that definite treatment and eradication of this bacterium could be a cure or to reduce the severity and course of migraine headaches. Tehran University of Medical Sciences 2015-07-06 /pmc/articles/PMC4662684/ /pubmed/26622976 Text en Copyright © 2015 Iranian Neurological Association, and Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ansari, Behnaz Basiri, Keivan Meamar, Rokhsareh Chitsaz, Ahmad Nematollahi, Shahrzad Association of Helicobacter pylori antibodies and severity of migraine attack |
title | Association of Helicobacter pylori antibodies and severity of migraine attack |
title_full | Association of Helicobacter pylori antibodies and severity of migraine attack |
title_fullStr | Association of Helicobacter pylori antibodies and severity of migraine attack |
title_full_unstemmed | Association of Helicobacter pylori antibodies and severity of migraine attack |
title_short | Association of Helicobacter pylori antibodies and severity of migraine attack |
title_sort | association of helicobacter pylori antibodies and severity of migraine attack |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662684/ https://www.ncbi.nlm.nih.gov/pubmed/26622976 |
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