Single-dose pharmacokinetics of 2 or 3 tablets of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155) under fed and fasted conditions: two randomized open-label trials

BACKGROUND: Biphasic immediate-release (IR)/extended-release (ER) hydrocodone bitartrate (HB)/acetaminophen (APAP) 7.5/325-mg tablets are formulated with gastroretentive ER drug delivery technology that has been associated with clinically meaningful food effects in other approved products. Two phase...

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Detalles Bibliográficos
Autores principales: Devarakonda, Krishna, Kostenbader, Kenneth, Giuliani, Michael J., Young, Jim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662814/
https://www.ncbi.nlm.nih.gov/pubmed/26614499
http://dx.doi.org/10.1186/s40360-015-0032-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662814/
https://www.ncbi.nlm.nih.gov/pubmed/26614499
http://dx.doi.org/10.1186/s40360-015-0032-y

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