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Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo
BACKGROUND: Access to antiretroviral treatment (ART) in resource-limited countries has increased significantly but scaling-up ART into semi-rural and rural areas is more recent. Information on treatment outcome in such areas is still very limited notably due to additional difficulties to manage ART...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662816/ https://www.ncbi.nlm.nih.gov/pubmed/26617663 http://dx.doi.org/10.1186/s12981-015-0082-7 |
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author | Konou, Abla A. Salou, Mounerou Vidal, Nicole Kodah, Pascal Kombate, Damobé Kpanla, Pyabalo Nabroulaba, Tchabia Nyametso, Djifa Singo-Tokofaï, Assétina Pitche, Palokinam Delaporte, Eric Prince-David, Mireille Peeters, Martine Dagnra, Anoumou Y. |
author_facet | Konou, Abla A. Salou, Mounerou Vidal, Nicole Kodah, Pascal Kombate, Damobé Kpanla, Pyabalo Nabroulaba, Tchabia Nyametso, Djifa Singo-Tokofaï, Assétina Pitche, Palokinam Delaporte, Eric Prince-David, Mireille Peeters, Martine Dagnra, Anoumou Y. |
author_sort | Konou, Abla A. |
collection | PubMed |
description | BACKGROUND: Access to antiretroviral treatment (ART) in resource-limited countries has increased significantly but scaling-up ART into semi-rural and rural areas is more recent. Information on treatment outcome in such areas is still very limited notably due to additional difficulties to manage ART in these areas. RESULTS: 387 HIV-1 infected adults (≥18 years) were consecutively enrolled when attending healthcare services for their routine medical visit at 12 or 24 months on first-line ART in five HIV care centers (four semi-rural and one rural). Among them, 102 patients were on first-line ART for 12 ± 2 months (M12) and 285 for 24 ± 2 months (M24). Virological failure was observed in 70 (18.1 %) patients ranging from 13.9 to 31.6 % at M12 and from 8.1 to 22.4 % at M24 across the different sites. For 67/70 patients, sequencing was successful and drug resistance mutations were observed in 65 (97 %). The global prevalence of drug resistance in the study population was thus at least 16.8 % (65/387). Moreover, 32 (8.3 %) and 27 (6.9 %) patients were either on a completely ineffective ART regime or with only a single drug active. Several patients accumulated high numbers of mutations and developed also cross-resistance to abacavir, didanosine or the new NNRTI drugs like etravirine and rilpivirine. CONCLUSION: The observations on ART treatment outcome from ART clinics in semi-rural areas are close to previous observations in Lomé, the capital city suggesting that national ART-programme management plays a role in treatment outcome. |
format | Online Article Text |
id | pubmed-4662816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-46628162015-11-29 Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo Konou, Abla A. Salou, Mounerou Vidal, Nicole Kodah, Pascal Kombate, Damobé Kpanla, Pyabalo Nabroulaba, Tchabia Nyametso, Djifa Singo-Tokofaï, Assétina Pitche, Palokinam Delaporte, Eric Prince-David, Mireille Peeters, Martine Dagnra, Anoumou Y. AIDS Res Ther Short Report BACKGROUND: Access to antiretroviral treatment (ART) in resource-limited countries has increased significantly but scaling-up ART into semi-rural and rural areas is more recent. Information on treatment outcome in such areas is still very limited notably due to additional difficulties to manage ART in these areas. RESULTS: 387 HIV-1 infected adults (≥18 years) were consecutively enrolled when attending healthcare services for their routine medical visit at 12 or 24 months on first-line ART in five HIV care centers (four semi-rural and one rural). Among them, 102 patients were on first-line ART for 12 ± 2 months (M12) and 285 for 24 ± 2 months (M24). Virological failure was observed in 70 (18.1 %) patients ranging from 13.9 to 31.6 % at M12 and from 8.1 to 22.4 % at M24 across the different sites. For 67/70 patients, sequencing was successful and drug resistance mutations were observed in 65 (97 %). The global prevalence of drug resistance in the study population was thus at least 16.8 % (65/387). Moreover, 32 (8.3 %) and 27 (6.9 %) patients were either on a completely ineffective ART regime or with only a single drug active. Several patients accumulated high numbers of mutations and developed also cross-resistance to abacavir, didanosine or the new NNRTI drugs like etravirine and rilpivirine. CONCLUSION: The observations on ART treatment outcome from ART clinics in semi-rural areas are close to previous observations in Lomé, the capital city suggesting that national ART-programme management plays a role in treatment outcome. BioMed Central 2015-11-27 /pmc/articles/PMC4662816/ /pubmed/26617663 http://dx.doi.org/10.1186/s12981-015-0082-7 Text en © Konou et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Short Report Konou, Abla A. Salou, Mounerou Vidal, Nicole Kodah, Pascal Kombate, Damobé Kpanla, Pyabalo Nabroulaba, Tchabia Nyametso, Djifa Singo-Tokofaï, Assétina Pitche, Palokinam Delaporte, Eric Prince-David, Mireille Peeters, Martine Dagnra, Anoumou Y. Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo |
title | Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo |
title_full | Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo |
title_fullStr | Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo |
title_full_unstemmed | Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo |
title_short | Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo |
title_sort | virological outcome among hiv-1 infected patients on first-line antiretroviral treatment in semi-rural hiv clinics in togo |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662816/ https://www.ncbi.nlm.nih.gov/pubmed/26617663 http://dx.doi.org/10.1186/s12981-015-0082-7 |
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