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Serum Aminotransferases in Thai Children With Dengue Infection

BACKGROUND: Hepatic manifestations are one of the unusual manifestations of dengue infection. OBJECTIVES: We conducted this study in order to study the pattern of serum aminotransferases and sequential changes before and after shock in Thai children with dengue infection. PATIENTS AND METHODS: Child...

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Autores principales: Prommalikit, Olarn, Thisyakorn, Usa, Thisyakorn, Chule
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662847/
https://www.ncbi.nlm.nih.gov/pubmed/26635947
http://dx.doi.org/10.5812/ijp.443
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author Prommalikit, Olarn
Thisyakorn, Usa
Thisyakorn, Chule
author_facet Prommalikit, Olarn
Thisyakorn, Usa
Thisyakorn, Chule
author_sort Prommalikit, Olarn
collection PubMed
description BACKGROUND: Hepatic manifestations are one of the unusual manifestations of dengue infection. OBJECTIVES: We conducted this study in order to study the pattern of serum aminotransferases and sequential changes before and after shock in Thai children with dengue infection. PATIENTS AND METHODS: Children who were clinically and serologically diagnosed as dengue infection and were admitted to King Chulalongkorn Memorial Hospital during a peroid of one year were enrolled. They were clinically classified into a non-shock group and a shock group. The majority of serum aminotransferases including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were obtained within a week after the onset of fever and until 3 days after shock in the shock group. Student t-test and median in boxplot form were used for statistical analysis. RESULTS: We enrolled 127 children with a mean age of 7.6 ± 3.6 years. The incidence of abnormal AST and ALT levels was 97.4% and 50.0% in the shock group, and 91.8% and 44.9% in the non-shock group respectively. 29% and 15.4% of the patients in shock group and only 10.2% and 4.1% in non-shock group had the respective AST and ALT levels > 200 U/L. Serum aminotransferase levels were significantly higher in the shock group when compared to the non-shock group. AST tended to increase starting from one day before shock and continued to increase within a few days whereas ALT was less likely to be affected. CONCLUSIONS: Elevated serum aminotransferases are a common finding in children with dengue infection and the levels of AST are higher than those of ALT. Patients with shock have significantly higher aminotransferase levels that increase up to 3 days after shock.
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spelling pubmed-46628472015-12-03 Serum Aminotransferases in Thai Children With Dengue Infection Prommalikit, Olarn Thisyakorn, Usa Thisyakorn, Chule Iran J Pediatr Research Article BACKGROUND: Hepatic manifestations are one of the unusual manifestations of dengue infection. OBJECTIVES: We conducted this study in order to study the pattern of serum aminotransferases and sequential changes before and after shock in Thai children with dengue infection. PATIENTS AND METHODS: Children who were clinically and serologically diagnosed as dengue infection and were admitted to King Chulalongkorn Memorial Hospital during a peroid of one year were enrolled. They were clinically classified into a non-shock group and a shock group. The majority of serum aminotransferases including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were obtained within a week after the onset of fever and until 3 days after shock in the shock group. Student t-test and median in boxplot form were used for statistical analysis. RESULTS: We enrolled 127 children with a mean age of 7.6 ± 3.6 years. The incidence of abnormal AST and ALT levels was 97.4% and 50.0% in the shock group, and 91.8% and 44.9% in the non-shock group respectively. 29% and 15.4% of the patients in shock group and only 10.2% and 4.1% in non-shock group had the respective AST and ALT levels > 200 U/L. Serum aminotransferase levels were significantly higher in the shock group when compared to the non-shock group. AST tended to increase starting from one day before shock and continued to increase within a few days whereas ALT was less likely to be affected. CONCLUSIONS: Elevated serum aminotransferases are a common finding in children with dengue infection and the levels of AST are higher than those of ALT. Patients with shock have significantly higher aminotransferase levels that increase up to 3 days after shock. Kowsar 2015-12-23 2015-12 /pmc/articles/PMC4662847/ /pubmed/26635947 http://dx.doi.org/10.5812/ijp.443 Text en Copyright © 2015, Growth & Development Research Center. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Prommalikit, Olarn
Thisyakorn, Usa
Thisyakorn, Chule
Serum Aminotransferases in Thai Children With Dengue Infection
title Serum Aminotransferases in Thai Children With Dengue Infection
title_full Serum Aminotransferases in Thai Children With Dengue Infection
title_fullStr Serum Aminotransferases in Thai Children With Dengue Infection
title_full_unstemmed Serum Aminotransferases in Thai Children With Dengue Infection
title_short Serum Aminotransferases in Thai Children With Dengue Infection
title_sort serum aminotransferases in thai children with dengue infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662847/
https://www.ncbi.nlm.nih.gov/pubmed/26635947
http://dx.doi.org/10.5812/ijp.443
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