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Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies

OBJECTIVE: We compared the performance of the 50-g glucose challenge test (GCT) in singleton versus twin pregnancies and investigated the need for adjusting GCT cutoff values for gestational diabetes mellitus (GDM) in twin pregnancies among Korean women. METHODS: A retrospective chart review was per...

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Autores principales: Jung, Yun Ji, Kwon, Ja Young, Cho, Hee Young, Park, Yong-Won, Kim, Young-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663220/
https://www.ncbi.nlm.nih.gov/pubmed/26623406
http://dx.doi.org/10.5468/ogs.2015.58.6.439
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author Jung, Yun Ji
Kwon, Ja Young
Cho, Hee Young
Park, Yong-Won
Kim, Young-Han
author_facet Jung, Yun Ji
Kwon, Ja Young
Cho, Hee Young
Park, Yong-Won
Kim, Young-Han
author_sort Jung, Yun Ji
collection PubMed
description OBJECTIVE: We compared the performance of the 50-g glucose challenge test (GCT) in singleton versus twin pregnancies and investigated the need for adjusting GCT cutoff values for gestational diabetes mellitus (GDM) in twin pregnancies among Korean women. METHODS: A retrospective chart review was performed in women who underwent GCT at 24 to 28 weeks' gestation and delivered in our department between January 2000 and April 2008. GCT performance was compared between singleton and twin pregnancies for an ideal cutoff value of the GCT for GDM screening. RESULTS: GCT results were available in 3,578 pregnancies (3,435 singleton and 143 twin pregnancies). The mean GCT value was higher in the twin group than in the singleton group. Women in the twin group had a higher mean GCT value (P=0.043) and a higher incidence of GCT ≥130, ≥135, and ≥140 mg/dL (P=0.014, 0.005, and 0.015, respectively). The false positive rate for GCT ≥140 mg/dL was significantly higher in the twin than in the singleton group (P=0.042). The optimal GCT screening cutoff value appears to be ≥145 mg/dL in twin pregnancies. CONCLUSION: Our study demonstrates that the GCT is associated with a higher false positive rate in twin rather than singleton pregnancies. This study suggests we should consider adjusting the GCT cutoff value for GDM in Korean twin pregnancies.
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spelling pubmed-46632202015-11-30 Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies Jung, Yun Ji Kwon, Ja Young Cho, Hee Young Park, Yong-Won Kim, Young-Han Obstet Gynecol Sci Original Article OBJECTIVE: We compared the performance of the 50-g glucose challenge test (GCT) in singleton versus twin pregnancies and investigated the need for adjusting GCT cutoff values for gestational diabetes mellitus (GDM) in twin pregnancies among Korean women. METHODS: A retrospective chart review was performed in women who underwent GCT at 24 to 28 weeks' gestation and delivered in our department between January 2000 and April 2008. GCT performance was compared between singleton and twin pregnancies for an ideal cutoff value of the GCT for GDM screening. RESULTS: GCT results were available in 3,578 pregnancies (3,435 singleton and 143 twin pregnancies). The mean GCT value was higher in the twin group than in the singleton group. Women in the twin group had a higher mean GCT value (P=0.043) and a higher incidence of GCT ≥130, ≥135, and ≥140 mg/dL (P=0.014, 0.005, and 0.015, respectively). The false positive rate for GCT ≥140 mg/dL was significantly higher in the twin than in the singleton group (P=0.042). The optimal GCT screening cutoff value appears to be ≥145 mg/dL in twin pregnancies. CONCLUSION: Our study demonstrates that the GCT is associated with a higher false positive rate in twin rather than singleton pregnancies. This study suggests we should consider adjusting the GCT cutoff value for GDM in Korean twin pregnancies. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2015-11 2015-11-16 /pmc/articles/PMC4663220/ /pubmed/26623406 http://dx.doi.org/10.5468/ogs.2015.58.6.439 Text en Copyright © 2015 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jung, Yun Ji
Kwon, Ja Young
Cho, Hee Young
Park, Yong-Won
Kim, Young-Han
Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies
title Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies
title_full Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies
title_fullStr Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies
title_full_unstemmed Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies
title_short Comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies
title_sort comparison of the performance of screening test for gestational diabetes in singleton versus twin pregnancies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663220/
https://www.ncbi.nlm.nih.gov/pubmed/26623406
http://dx.doi.org/10.5468/ogs.2015.58.6.439
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