Cargando…

SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?

Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. In the past decade, a growing body of evidence has indicated an important role...

Descripción completa

Detalles Bibliográficos
Autores principales: Mu, Qinghui, Zhang, Husen, Luo, Xin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/
https://www.ncbi.nlm.nih.gov/pubmed/26648937
http://dx.doi.org/10.3389/fimmu.2015.00608
_version_ 1782403260551790592
author Mu, Qinghui
Zhang, Husen
Luo, Xin M.
author_facet Mu, Qinghui
Zhang, Husen
Luo, Xin M.
author_sort Mu, Qinghui
collection PubMed
description Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. In the past decade, a growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus. Several recent studies have suggested that alterations of the gut microbial composition may be correlated with SLE disease manifestations, while the exact roles of either symbiotic or pathogenic microbes in this disease remain to be explored. Elucidation of the roles of gut microbes – as well as the roles of diet that can modulate the composition of gut microbes – in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new therapies. In this review, we aim to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis.
format Online
Article
Text
id pubmed-4663251
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-46632512015-12-08 SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? Mu, Qinghui Zhang, Husen Luo, Xin M. Front Immunol Immunology Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease. Despite years of study, the etiology of SLE is still unclear. Both genetic and environmental factors have been implicated in the disease mechanisms. In the past decade, a growing body of evidence has indicated an important role of gut microbes in the development of autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, and multiple sclerosis. However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus. Several recent studies have suggested that alterations of the gut microbial composition may be correlated with SLE disease manifestations, while the exact roles of either symbiotic or pathogenic microbes in this disease remain to be explored. Elucidation of the roles of gut microbes – as well as the roles of diet that can modulate the composition of gut microbes – in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new therapies. In this review, we aim to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis. Frontiers Media S.A. 2015-11-30 /pmc/articles/PMC4663251/ /pubmed/26648937 http://dx.doi.org/10.3389/fimmu.2015.00608 Text en Copyright © 2015 Mu, Zhang and Luo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Mu, Qinghui
Zhang, Husen
Luo, Xin M.
SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?
title SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?
title_full SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?
title_fullStr SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?
title_full_unstemmed SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?
title_short SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?
title_sort sle: another autoimmune disorder influenced by microbes and diet?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/
https://www.ncbi.nlm.nih.gov/pubmed/26648937
http://dx.doi.org/10.3389/fimmu.2015.00608
work_keys_str_mv AT muqinghui sleanotherautoimmunedisorderinfluencedbymicrobesanddiet
AT zhanghusen sleanotherautoimmunedisorderinfluencedbymicrobesanddiet
AT luoxinm sleanotherautoimmunedisorderinfluencedbymicrobesanddiet