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tPA Deficiency in Mice Leads to Rearrangement in the Cerebrovascular Tree and Cerebroventricular Malformations

The serine protease tissue-type plasminogen activator (tPA) is used as a thrombolytic agent in the management of ischemic stroke, but concerns for hemorrhagic conversion greatly limits the number of patients that receive this treatment. It has been suggested that the bleeding complications associate...

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Detalles Bibliográficos
Autores principales:	Stefanitsch, Christina, Lawrence, Anna-Lisa E., Olverling, Anna, Nilsson, Ingrid, Fredriksson, Linda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663266/ https://www.ncbi.nlm.nih.gov/pubmed/26648843 http://dx.doi.org/10.3389/fncel.2015.00456

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