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Current Status of Norovirus Infections in Children in Sub-Saharan Africa

Noroviruses are a leading cause of acute sporadic gastroenteritis worldwide. In Sub-Saharan Africa, information regarding norovirus infections in children is scarce. A systematic review of studies performed between 1993 and June 2015 was conducted to establish the genotypic distribution and prevalen...

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Autor principal: Munjita, Samuel Munalula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663330/
https://www.ncbi.nlm.nih.gov/pubmed/26649055
http://dx.doi.org/10.1155/2015/309648
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author Munjita, Samuel Munalula
author_facet Munjita, Samuel Munalula
author_sort Munjita, Samuel Munalula
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description Noroviruses are a leading cause of acute sporadic gastroenteritis worldwide. In Sub-Saharan Africa, information regarding norovirus infections in children is scarce. A systematic review of studies performed between 1993 and June 2015 was conducted to establish the genotypic distribution and prevalence of norovirus infections in children (≤17) in Sub-Saharan Africa. Analysis of data from 19 studies involving 8,399 samples from children with symptomatic and nonsymptomatic gastroenteritis revealed prevalence of 12.6% (range 4.6% to 32.4%). The prevalence of norovirus infections was higher in symptomatic children (14.2%) than asymptomatic children (9.2%). Genogroup II (GII) was the most prevalent genogroup accounting for 76.4% of all the reported norovirus infections. The rest of the infections were GI (21.7%) and GI/GII (1.9%). The most common genotypes were GII.4 (65.2%), GI.7 (33.3%), and GI.3 (21.3%). These statistics were calculated from studies carried out in 12 out of 48 Sub-Saharan African countries. Therefore, more studies involving several countries are required to determine fully the epidemiology of noroviruses and their contribution to childhood diarrhoea in Sub-Saharan Africa.
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spelling pubmed-46633302015-12-08 Current Status of Norovirus Infections in Children in Sub-Saharan Africa Munjita, Samuel Munalula J Trop Med Review Article Noroviruses are a leading cause of acute sporadic gastroenteritis worldwide. In Sub-Saharan Africa, information regarding norovirus infections in children is scarce. A systematic review of studies performed between 1993 and June 2015 was conducted to establish the genotypic distribution and prevalence of norovirus infections in children (≤17) in Sub-Saharan Africa. Analysis of data from 19 studies involving 8,399 samples from children with symptomatic and nonsymptomatic gastroenteritis revealed prevalence of 12.6% (range 4.6% to 32.4%). The prevalence of norovirus infections was higher in symptomatic children (14.2%) than asymptomatic children (9.2%). Genogroup II (GII) was the most prevalent genogroup accounting for 76.4% of all the reported norovirus infections. The rest of the infections were GI (21.7%) and GI/GII (1.9%). The most common genotypes were GII.4 (65.2%), GI.7 (33.3%), and GI.3 (21.3%). These statistics were calculated from studies carried out in 12 out of 48 Sub-Saharan African countries. Therefore, more studies involving several countries are required to determine fully the epidemiology of noroviruses and their contribution to childhood diarrhoea in Sub-Saharan Africa. Hindawi Publishing Corporation 2015 2015-11-16 /pmc/articles/PMC4663330/ /pubmed/26649055 http://dx.doi.org/10.1155/2015/309648 Text en Copyright © 2015 Samuel Munalula Munjita. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Munjita, Samuel Munalula
Current Status of Norovirus Infections in Children in Sub-Saharan Africa
title Current Status of Norovirus Infections in Children in Sub-Saharan Africa
title_full Current Status of Norovirus Infections in Children in Sub-Saharan Africa
title_fullStr Current Status of Norovirus Infections in Children in Sub-Saharan Africa
title_full_unstemmed Current Status of Norovirus Infections in Children in Sub-Saharan Africa
title_short Current Status of Norovirus Infections in Children in Sub-Saharan Africa
title_sort current status of norovirus infections in children in sub-saharan africa
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663330/
https://www.ncbi.nlm.nih.gov/pubmed/26649055
http://dx.doi.org/10.1155/2015/309648
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