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Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset

Introduction. Neonatal septicemia is defined as infection in the first 28 days of life. Early-onset neonatal septicemia and late-onset neonatal septicemia are defined as illnesses appearing from birth to three days and from four to twenty-eight days postnatally, respectively. Methods. In this cross-...

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Autores principales: Ansari, Shamshul, Nepal, Hari Prasad, Gautam, Rajendra, Shrestha, Sony, Neopane, Puja, Chapagain, Moti Lal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663350/
https://www.ncbi.nlm.nih.gov/pubmed/26649057
http://dx.doi.org/10.1155/2015/379806
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author Ansari, Shamshul
Nepal, Hari Prasad
Gautam, Rajendra
Shrestha, Sony
Neopane, Puja
Chapagain, Moti Lal
author_facet Ansari, Shamshul
Nepal, Hari Prasad
Gautam, Rajendra
Shrestha, Sony
Neopane, Puja
Chapagain, Moti Lal
author_sort Ansari, Shamshul
collection PubMed
description Introduction. Neonatal septicemia is defined as infection in the first 28 days of life. Early-onset neonatal septicemia and late-onset neonatal septicemia are defined as illnesses appearing from birth to three days and from four to twenty-eight days postnatally, respectively. Methods. In this cross-sectional study, blood samples from the suspected infants were collected and processed in the bacteriology laboratory. The growth was identified by standard microbiological protocol and the antibiotic sensitivity testing was carried out by modified Kirby-Bauer disk diffusion method. Results. Among total suspected cases, the septicemia was confirmed in 116 (12.6%) neonates. Early-onset septicemia (EOS) was observed in 82 infants and late-onset septicemia (LOS) in 34 infants. Coagulase-negative staphylococcus (CoNS) (46.6%) was the predominant Gram-positive organism isolated from EOS as well as from LOS cases followed by Staphylococcus aureus (14.6%). Acinetobacter species (9.5%) was the predominant Gram-negative organism followed by Klebsiella pneumoniae (7.7%). Conclusions. The result of our study reveals that the CoNS, Staphylococcus aureus, Acinetobacter spp., and Klebsiella pneumoniae are the most common etiological agents of neonatal septicemia. In particular, since rate of CoNS causing sepsis is alarming, prompting concern to curb the excess burden of CoNS infection is necessary.
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spelling pubmed-46633502015-12-08 Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset Ansari, Shamshul Nepal, Hari Prasad Gautam, Rajendra Shrestha, Sony Neopane, Puja Chapagain, Moti Lal Int J Pediatr Research Article Introduction. Neonatal septicemia is defined as infection in the first 28 days of life. Early-onset neonatal septicemia and late-onset neonatal septicemia are defined as illnesses appearing from birth to three days and from four to twenty-eight days postnatally, respectively. Methods. In this cross-sectional study, blood samples from the suspected infants were collected and processed in the bacteriology laboratory. The growth was identified by standard microbiological protocol and the antibiotic sensitivity testing was carried out by modified Kirby-Bauer disk diffusion method. Results. Among total suspected cases, the septicemia was confirmed in 116 (12.6%) neonates. Early-onset septicemia (EOS) was observed in 82 infants and late-onset septicemia (LOS) in 34 infants. Coagulase-negative staphylococcus (CoNS) (46.6%) was the predominant Gram-positive organism isolated from EOS as well as from LOS cases followed by Staphylococcus aureus (14.6%). Acinetobacter species (9.5%) was the predominant Gram-negative organism followed by Klebsiella pneumoniae (7.7%). Conclusions. The result of our study reveals that the CoNS, Staphylococcus aureus, Acinetobacter spp., and Klebsiella pneumoniae are the most common etiological agents of neonatal septicemia. In particular, since rate of CoNS causing sepsis is alarming, prompting concern to curb the excess burden of CoNS infection is necessary. Hindawi Publishing Corporation 2015 2015-11-16 /pmc/articles/PMC4663350/ /pubmed/26649057 http://dx.doi.org/10.1155/2015/379806 Text en Copyright © 2015 Shamshul Ansari et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ansari, Shamshul
Nepal, Hari Prasad
Gautam, Rajendra
Shrestha, Sony
Neopane, Puja
Chapagain, Moti Lal
Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset
title Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset
title_full Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset
title_fullStr Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset
title_full_unstemmed Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset
title_short Neonatal Septicemia in Nepal: Early-Onset versus Late-Onset
title_sort neonatal septicemia in nepal: early-onset versus late-onset
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663350/
https://www.ncbi.nlm.nih.gov/pubmed/26649057
http://dx.doi.org/10.1155/2015/379806
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