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Microenvironmental Hypoxia regulates FLT3 expression and biology in AML

Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase constitutively expressed by acute myeloid leukaemia (AML) blasts. In addition, 25% of AML patients harbour a FLT3-ITD mutation, associated with inferior outcome due to increased relapse rate. Relapse might be propagated by interactions...

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Detalles Bibliográficos
Autores principales:	Sironi, Silvia, Wagner, Michaela, Kuett, Alexander, Drolle, Heidrun, Polzer, Harald, Spiekermann, Karsten, Rieger, Christina, Fiegl, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663471/ https://www.ncbi.nlm.nih.gov/pubmed/26617391 http://dx.doi.org/10.1038/srep17550

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