Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet

High-fat diet (HFD) triggers insulin resistance and diabetes mellitus, but their link remains unclear. Characterization of overt hyperglycemia in insulin receptor mutant (Insr(P1195L/+)) mice exposed to HFD (Insr(P1195L/+)/HFD mice) revealed increased glucose-6-phosphatase (G6pc) expression in liver...

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Detalles Bibliográficos
Autores principales: Lee, Eun Young, Sakurai, Kenichi, Zhang, Xilin, Toda, Chitoku, Tanaka, Tomoaki, Jiang, Meizi, Shirasawa, Takuji, Tachibana, Kaori, Yokote, Koutaro, Vidal-Puig, Antonio, Minokoshi, Yasuhiko, Miki, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663474/
https://www.ncbi.nlm.nih.gov/pubmed/26615883
http://dx.doi.org/10.1038/srep17565

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