Quantitative Profiling of the Effects of Vanoxerine on Human Cardiac Ion Channels and its Application to Cardiac Risk

Vanoxerine has been in clinical trials for Parkinsonism, depression and cocaine addiction but lacked efficacy. Although a potent blocker of hERG, it produced no serious adverse events. We attributed the unexpected result to offsetting Multiple Ion Channel Effects (MICE). Vanoxerine’s effects were st...

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Detalles Bibliográficos
Autores principales: Obejero-Paz, Carlos A., Bruening-Wright, Andrew, Kramer, James, Hawryluk, Peter, Tatalovic, Milos, Dittrich, Howard C., Brown, Arthur M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663487/
https://www.ncbi.nlm.nih.gov/pubmed/26616666
http://dx.doi.org/10.1038/srep17623

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