Drug target prioritization by perturbed gene expression and network information

Drugs bind to their target proteins, which interact with downstream effectors and ultimately perturb the transcriptome of a cancer cell. These perturbations reveal information about their source, i.e., drugs’ targets. Here, we investigate whether these perturbations and protein interaction networks...

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Detalles Bibliográficos
Autores principales: Isik, Zerrin, Baldow, Christoph, Cannistraci, Carlo Vittorio, Schroeder, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663505/
https://www.ncbi.nlm.nih.gov/pubmed/26615774
http://dx.doi.org/10.1038/srep17417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663505/
https://www.ncbi.nlm.nih.gov/pubmed/26615774
http://dx.doi.org/10.1038/srep17417

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