Cargando…

Acupoint Injection of Onabotulinumtoxin A for Migraines

Onabotulinumtoxin A (BoNTA) has been reported to be effective in the therapy for migraines. Acupuncture has been used worldwide for the treatment of migraine attacks. Injection of a small amount of drug at acupuncture points is an innovation as compared to traditional acupuncture. The purpose of thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Min, Xie, Jun-Fan, Kong, Xiang-Pan, Zhang, Yi, Shao, Yu-Feng, Wang, Can, Ren, Wen-Ting, Cui, Guang-Fu, Xin, Le, Hou, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663513/
https://www.ncbi.nlm.nih.gov/pubmed/26529014
http://dx.doi.org/10.3390/toxins7114442
_version_ 1782403311989686272
author Hou, Min
Xie, Jun-Fan
Kong, Xiang-Pan
Zhang, Yi
Shao, Yu-Feng
Wang, Can
Ren, Wen-Ting
Cui, Guang-Fu
Xin, Le
Hou, Yi-Ping
author_facet Hou, Min
Xie, Jun-Fan
Kong, Xiang-Pan
Zhang, Yi
Shao, Yu-Feng
Wang, Can
Ren, Wen-Ting
Cui, Guang-Fu
Xin, Le
Hou, Yi-Ping
author_sort Hou, Min
collection PubMed
description Onabotulinumtoxin A (BoNTA) has been reported to be effective in the therapy for migraines. Acupuncture has been used worldwide for the treatment of migraine attacks. Injection of a small amount of drug at acupuncture points is an innovation as compared to traditional acupuncture. The purpose of this study was to evaluate and compare the effectiveness of fixed (muscle)-site and acupoint-site injections of BoNTA for migraine therapy in a randomized, double-blinded, placebo-controlled clinical trial extending over four months. Subjects with both episodic and chronic migraines respectively received a placebo (n = 19) or BoNTA (2.5 U each site, 25 U per subject) injection at fixed-sites (n = 41) including occipitofrontalis, corrugator supercilii, temporalis and trapeziue, or at acupoint-sites (n = 42) including Yintang (EX-HN3), Taiyang (EX-HN5), Baihui (GV20), Shuaigu (GB8), Fengchi (GB20) and Tianzhu (BL10). The variations between baseline and BoNTA post-injection for four months were calculated monthly as outcome measures. BoNTA injections at fixed-sites and acupoint-sites significantly reduced the migraine attack frequency, intensity, duration and associated symptoms for four months compared with placebo (p < 0.01). The efficacy of BoNTA for migraines in the acupoint-site group (93% improvement) was more significant than that in the fixed-site group (85% improvement) (p < 0.01). BoNTA administration for migraines is effective, and at acupoint-sites shows more efficacy than at fixed-sites. Further blinded studies are necessary to establish the efficacy of a low dose toxin (25 U) introduced with this methodology in chronic and episodic migraines.
format Online
Article
Text
id pubmed-4663513
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-46635132015-12-10 Acupoint Injection of Onabotulinumtoxin A for Migraines Hou, Min Xie, Jun-Fan Kong, Xiang-Pan Zhang, Yi Shao, Yu-Feng Wang, Can Ren, Wen-Ting Cui, Guang-Fu Xin, Le Hou, Yi-Ping Toxins (Basel) Article Onabotulinumtoxin A (BoNTA) has been reported to be effective in the therapy for migraines. Acupuncture has been used worldwide for the treatment of migraine attacks. Injection of a small amount of drug at acupuncture points is an innovation as compared to traditional acupuncture. The purpose of this study was to evaluate and compare the effectiveness of fixed (muscle)-site and acupoint-site injections of BoNTA for migraine therapy in a randomized, double-blinded, placebo-controlled clinical trial extending over four months. Subjects with both episodic and chronic migraines respectively received a placebo (n = 19) or BoNTA (2.5 U each site, 25 U per subject) injection at fixed-sites (n = 41) including occipitofrontalis, corrugator supercilii, temporalis and trapeziue, or at acupoint-sites (n = 42) including Yintang (EX-HN3), Taiyang (EX-HN5), Baihui (GV20), Shuaigu (GB8), Fengchi (GB20) and Tianzhu (BL10). The variations between baseline and BoNTA post-injection for four months were calculated monthly as outcome measures. BoNTA injections at fixed-sites and acupoint-sites significantly reduced the migraine attack frequency, intensity, duration and associated symptoms for four months compared with placebo (p < 0.01). The efficacy of BoNTA for migraines in the acupoint-site group (93% improvement) was more significant than that in the fixed-site group (85% improvement) (p < 0.01). BoNTA administration for migraines is effective, and at acupoint-sites shows more efficacy than at fixed-sites. Further blinded studies are necessary to establish the efficacy of a low dose toxin (25 U) introduced with this methodology in chronic and episodic migraines. MDPI 2015-10-30 /pmc/articles/PMC4663513/ /pubmed/26529014 http://dx.doi.org/10.3390/toxins7114442 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hou, Min
Xie, Jun-Fan
Kong, Xiang-Pan
Zhang, Yi
Shao, Yu-Feng
Wang, Can
Ren, Wen-Ting
Cui, Guang-Fu
Xin, Le
Hou, Yi-Ping
Acupoint Injection of Onabotulinumtoxin A for Migraines
title Acupoint Injection of Onabotulinumtoxin A for Migraines
title_full Acupoint Injection of Onabotulinumtoxin A for Migraines
title_fullStr Acupoint Injection of Onabotulinumtoxin A for Migraines
title_full_unstemmed Acupoint Injection of Onabotulinumtoxin A for Migraines
title_short Acupoint Injection of Onabotulinumtoxin A for Migraines
title_sort acupoint injection of onabotulinumtoxin a for migraines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663513/
https://www.ncbi.nlm.nih.gov/pubmed/26529014
http://dx.doi.org/10.3390/toxins7114442
work_keys_str_mv AT houmin acupointinjectionofonabotulinumtoxinaformigraines
AT xiejunfan acupointinjectionofonabotulinumtoxinaformigraines
AT kongxiangpan acupointinjectionofonabotulinumtoxinaformigraines
AT zhangyi acupointinjectionofonabotulinumtoxinaformigraines
AT shaoyufeng acupointinjectionofonabotulinumtoxinaformigraines
AT wangcan acupointinjectionofonabotulinumtoxinaformigraines
AT renwenting acupointinjectionofonabotulinumtoxinaformigraines
AT cuiguangfu acupointinjectionofonabotulinumtoxinaformigraines
AT xinle acupointinjectionofonabotulinumtoxinaformigraines
AT houyiping acupointinjectionofonabotulinumtoxinaformigraines