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Vitamin D(3) and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP(139–151) peptide. The effect of treating these mice...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663530/ https://www.ncbi.nlm.nih.gov/pubmed/26580651 http://dx.doi.org/10.3390/toxins7114730 |
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author | Al-Jaderi, Zaidoon Maghazachi, Azzam A. |
author_facet | Al-Jaderi, Zaidoon Maghazachi, Azzam A. |
author_sort | Al-Jaderi, Zaidoon |
collection | PubMed |
description | Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP(139–151) peptide. The effect of treating these mice with 1α,25-Dihydroxyvitamin D(3) (vitamin D(3)), or with monomethyl fumarate (MMF) was then examined. We observed that both vitamin D(3) and MMF inhibited and/or prevented EAE in these mice. These findings were corroborated with isolating natural killer (NK) cells from vitamin D(3)-treated or MMF-treated EAE mice that lysed immature or mature dendritic cells. The results support and extend other findings indicating that an important mechanism of action for drugs used to treat multiple sclerosis (MS) is to enhance NK cell lysis of dendritic cells. |
format | Online Article Text |
id | pubmed-4663530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46635302015-12-10 Vitamin D(3) and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis Al-Jaderi, Zaidoon Maghazachi, Azzam A. Toxins (Basel) Article Experimental autoimmune encephalomyelitis (EAE) is a CD4(+) T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP(139–151) peptide. The effect of treating these mice with 1α,25-Dihydroxyvitamin D(3) (vitamin D(3)), or with monomethyl fumarate (MMF) was then examined. We observed that both vitamin D(3) and MMF inhibited and/or prevented EAE in these mice. These findings were corroborated with isolating natural killer (NK) cells from vitamin D(3)-treated or MMF-treated EAE mice that lysed immature or mature dendritic cells. The results support and extend other findings indicating that an important mechanism of action for drugs used to treat multiple sclerosis (MS) is to enhance NK cell lysis of dendritic cells. MDPI 2015-11-13 /pmc/articles/PMC4663530/ /pubmed/26580651 http://dx.doi.org/10.3390/toxins7114730 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Al-Jaderi, Zaidoon Maghazachi, Azzam A. Vitamin D(3) and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
title | Vitamin D(3) and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
title_full | Vitamin D(3) and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
title_fullStr | Vitamin D(3) and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
title_full_unstemmed | Vitamin D(3) and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
title_short | Vitamin D(3) and Monomethyl Fumarate Enhance Natural Killer Cell Lysis of Dendritic Cells and Ameliorate the Clinical Score in Mice Suffering from Experimental Autoimmune Encephalomyelitis |
title_sort | vitamin d(3) and monomethyl fumarate enhance natural killer cell lysis of dendritic cells and ameliorate the clinical score in mice suffering from experimental autoimmune encephalomyelitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663530/ https://www.ncbi.nlm.nih.gov/pubmed/26580651 http://dx.doi.org/10.3390/toxins7114730 |
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