Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)

Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its select...

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Detalles Bibliográficos
Autores principales: Elmallah, Mohammed I. Y., Micheau, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663558/
https://www.ncbi.nlm.nih.gov/pubmed/26580630
http://dx.doi.org/10.3390/md13116884
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author Elmallah, Mohammed I. Y.
Micheau, Olivier
author_facet Elmallah, Mohammed I. Y.
Micheau, Olivier
author_sort Elmallah, Mohammed I. Y.
collection PubMed
description Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells.
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spelling pubmed-46635582015-12-10 Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Elmallah, Mohammed I. Y. Micheau, Olivier Mar Drugs Review Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer cells has attracted much attention in oncology. This review aims at discussing the main mechanisms by which TRAIL signaling is regulated and presenting how marine bioactive compounds have been found, so far, to overcome TRAIL resistance in tumor cells. MDPI 2015-11-13 /pmc/articles/PMC4663558/ /pubmed/26580630 http://dx.doi.org/10.3390/md13116884 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Elmallah, Mohammed I. Y.
Micheau, Olivier
Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_full Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_fullStr Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_full_unstemmed Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_short Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
title_sort marine drugs regulating apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (trail)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663558/
https://www.ncbi.nlm.nih.gov/pubmed/26580630
http://dx.doi.org/10.3390/md13116884
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