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Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial
Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663570/ https://www.ncbi.nlm.nih.gov/pubmed/26529006 http://dx.doi.org/10.3390/nu7115442 |
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author | López-Velázquez, Gabriel Parra-Ortiz, Minerva De la Mora-De la Mora, Ignacio García-Torres, Itzhel Enríquez-Flores, Sergio Alcántara-Ortigoza, Miguel Angel González-del Angel, Ariadna Velázquez-Aragón, José Ortiz-Hernández, Rosario Cruz-Rubio, José Manuel Villa-Barragán, Pablo Jiménez-Gutiérrez, Carlos Gutiérrez-Castrellón, Pedro |
author_facet | López-Velázquez, Gabriel Parra-Ortiz, Minerva De la Mora-De la Mora, Ignacio García-Torres, Itzhel Enríquez-Flores, Sergio Alcántara-Ortigoza, Miguel Angel González-del Angel, Ariadna Velázquez-Aragón, José Ortiz-Hernández, Rosario Cruz-Rubio, José Manuel Villa-Barragán, Pablo Jiménez-Gutiérrez, Carlos Gutiérrez-Castrellón, Pedro |
author_sort | López-Velázquez, Gabriel |
collection | PubMed |
description | Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated. Methods: This study aimed to demonstrate the efficacy as prebiotics of Metlin(®) and Metlos(®) in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes. Results: There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin(®) and Metlos(®). Conclusions: Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption. Trial Registration: ClinicalTrials.gov, NCT 01251783. |
format | Online Article Text |
id | pubmed-4663570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46635702015-12-10 Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial López-Velázquez, Gabriel Parra-Ortiz, Minerva De la Mora-De la Mora, Ignacio García-Torres, Itzhel Enríquez-Flores, Sergio Alcántara-Ortigoza, Miguel Angel González-del Angel, Ariadna Velázquez-Aragón, José Ortiz-Hernández, Rosario Cruz-Rubio, José Manuel Villa-Barragán, Pablo Jiménez-Gutiérrez, Carlos Gutiérrez-Castrellón, Pedro Nutrients Article Background: The importance of prebiotics consumption is increasing all over the world due to their beneficial effects on health. Production of better prebiotics from endemic plants raises possibilities to enhance nutritional effects in vulnerable population groups. Fructans derived from Agave Plant have demonstrated their safety and efficacy as prebiotics in animal models. Recently, the safety in humans of two fructans obtained from Agave tequilana (Metlin(®) and Metlos(®)) was demonstrated. Methods: This study aimed to demonstrate the efficacy as prebiotics of Metlin(®) and Metlos(®) in newborns of a randomized, double blind, controlled trial with a pilot study design. Biological samples were taken at 20 ± 7 days, and three months of age from healthy babies. Outcomes of efficacy include impact on immune response, serum ferritin, C-reactive protein, bone metabolism, and gut bacteria changes. Results: There were differences statistically significant for the groups of infants fed only with infant formula and with formula enriched with Metlin(®) and Metlos(®). Conclusions: Our results support the efficacy of Metlin(®) and Metlos(®) as prebiotics in humans, and stand the bases to recommend their consumption. Trial Registration: ClinicalTrials.gov, NCT 01251783. MDPI 2015-10-29 /pmc/articles/PMC4663570/ /pubmed/26529006 http://dx.doi.org/10.3390/nu7115442 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article López-Velázquez, Gabriel Parra-Ortiz, Minerva De la Mora-De la Mora, Ignacio García-Torres, Itzhel Enríquez-Flores, Sergio Alcántara-Ortigoza, Miguel Angel González-del Angel, Ariadna Velázquez-Aragón, José Ortiz-Hernández, Rosario Cruz-Rubio, José Manuel Villa-Barragán, Pablo Jiménez-Gutiérrez, Carlos Gutiérrez-Castrellón, Pedro Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial |
title | Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial |
title_full | Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial |
title_fullStr | Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial |
title_full_unstemmed | Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial |
title_short | Effects of Fructans from Mexican Agave in Newborns Fed with Infant Formula: A Randomized Controlled Trial |
title_sort | effects of fructans from mexican agave in newborns fed with infant formula: a randomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663570/ https://www.ncbi.nlm.nih.gov/pubmed/26529006 http://dx.doi.org/10.3390/nu7115442 |
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