Cargando…

Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project

Background: We assessed the still unclear effect of the overall alcohol-drinking pattern, beyond the amount of alcohol consumed, on the incidence of cardiovascular clinical disease (CVD). Methods: We followed 14,651 participants during up to 14 years. We built a score assessing simultaneously seven...

Descripción completa

Detalles Bibliográficos
Autores principales: Hernandez-Hernandez, Aitor, Gea, Alfredo, Ruiz-Canela, Miguel, Toledo, Estefania, Beunza, Juan-José, Bes-Rastrollo, Maira, Martinez-Gonzalez, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663584/
https://www.ncbi.nlm.nih.gov/pubmed/26556367
http://dx.doi.org/10.3390/nu7115456
_version_ 1782403328203816960
author Hernandez-Hernandez, Aitor
Gea, Alfredo
Ruiz-Canela, Miguel
Toledo, Estefania
Beunza, Juan-José
Bes-Rastrollo, Maira
Martinez-Gonzalez, Miguel A.
author_facet Hernandez-Hernandez, Aitor
Gea, Alfredo
Ruiz-Canela, Miguel
Toledo, Estefania
Beunza, Juan-José
Bes-Rastrollo, Maira
Martinez-Gonzalez, Miguel A.
author_sort Hernandez-Hernandez, Aitor
collection PubMed
description Background: We assessed the still unclear effect of the overall alcohol-drinking pattern, beyond the amount of alcohol consumed, on the incidence of cardiovascular clinical disease (CVD). Methods: We followed 14,651 participants during up to 14 years. We built a score assessing simultaneously seven dimensions of alcohol consumption to capture the conformity to a traditional Mediterranean alcohol-drinking pattern (MADP). It positively scored moderate alcohol intake, alcohol intake spread out over the week, low spirit consumption, preference for wine, red wine consumption, wine consumed during meals and avoidance of binge drinking. Results: During 142,177 person-years of follow-up, 127 incident cases of CVD (myocardial infarction, stroke or cardiovascular mortality) were identified. Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58–4.16)). This direct association with a departure from the traditional MADP was even stronger for cardiovascular mortality (HR (95% CI) = 3.35 (0.77–14.5)). Nevertheless, all these associations were statistically non-significant. Conclusion: Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD.
format Online
Article
Text
id pubmed-4663584
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-46635842015-12-10 Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project Hernandez-Hernandez, Aitor Gea, Alfredo Ruiz-Canela, Miguel Toledo, Estefania Beunza, Juan-José Bes-Rastrollo, Maira Martinez-Gonzalez, Miguel A. Nutrients Article Background: We assessed the still unclear effect of the overall alcohol-drinking pattern, beyond the amount of alcohol consumed, on the incidence of cardiovascular clinical disease (CVD). Methods: We followed 14,651 participants during up to 14 years. We built a score assessing simultaneously seven dimensions of alcohol consumption to capture the conformity to a traditional Mediterranean alcohol-drinking pattern (MADP). It positively scored moderate alcohol intake, alcohol intake spread out over the week, low spirit consumption, preference for wine, red wine consumption, wine consumed during meals and avoidance of binge drinking. Results: During 142,177 person-years of follow-up, 127 incident cases of CVD (myocardial infarction, stroke or cardiovascular mortality) were identified. Compared with the category of better conformity with the MADP, the low-adherence group exhibited a non-significantly higher risk (HR) of total CVD ((95% CI) = 1.55 (0.58–4.16)). This direct association with a departure from the traditional MADP was even stronger for cardiovascular mortality (HR (95% CI) = 3.35 (0.77–14.5)). Nevertheless, all these associations were statistically non-significant. Conclusion: Better conformity with the MADP seemed to be associated with lower cardiovascular risk in most point estimates; however, no significant results were found and more powered studies are needed to clarify the role of the MADP on CVD. MDPI 2015-11-05 /pmc/articles/PMC4663584/ /pubmed/26556367 http://dx.doi.org/10.3390/nu7115456 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hernandez-Hernandez, Aitor
Gea, Alfredo
Ruiz-Canela, Miguel
Toledo, Estefania
Beunza, Juan-José
Bes-Rastrollo, Maira
Martinez-Gonzalez, Miguel A.
Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project
title Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project
title_full Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project
title_fullStr Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project
title_full_unstemmed Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project
title_short Mediterranean Alcohol-Drinking Pattern and the Incidence of Cardiovascular Disease and Cardiovascular Mortality: The SUN Project
title_sort mediterranean alcohol-drinking pattern and the incidence of cardiovascular disease and cardiovascular mortality: the sun project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663584/
https://www.ncbi.nlm.nih.gov/pubmed/26556367
http://dx.doi.org/10.3390/nu7115456
work_keys_str_mv AT hernandezhernandezaitor mediterraneanalcoholdrinkingpatternandtheincidenceofcardiovasculardiseaseandcardiovascularmortalitythesunproject
AT geaalfredo mediterraneanalcoholdrinkingpatternandtheincidenceofcardiovasculardiseaseandcardiovascularmortalitythesunproject
AT ruizcanelamiguel mediterraneanalcoholdrinkingpatternandtheincidenceofcardiovasculardiseaseandcardiovascularmortalitythesunproject
AT toledoestefania mediterraneanalcoholdrinkingpatternandtheincidenceofcardiovasculardiseaseandcardiovascularmortalitythesunproject
AT beunzajuanjose mediterraneanalcoholdrinkingpatternandtheincidenceofcardiovasculardiseaseandcardiovascularmortalitythesunproject
AT besrastrollomaira mediterraneanalcoholdrinkingpatternandtheincidenceofcardiovasculardiseaseandcardiovascularmortalitythesunproject
AT martinezgonzalezmiguela mediterraneanalcoholdrinkingpatternandtheincidenceofcardiovasculardiseaseandcardiovascularmortalitythesunproject