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The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis

Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, di...

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Detalles Bibliográficos
Autores principales: Saponaro, Chiara, Gaggini, Melania, Carli, Fabrizia, Gastaldelli, Amalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663603/
https://www.ncbi.nlm.nih.gov/pubmed/26580649
http://dx.doi.org/10.3390/nu7115475
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author Saponaro, Chiara
Gaggini, Melania
Carli, Fabrizia
Gastaldelli, Amalia
author_facet Saponaro, Chiara
Gaggini, Melania
Carli, Fabrizia
Gastaldelli, Amalia
author_sort Saponaro, Chiara
collection PubMed
description Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, diabetes, fatty liver disease (NAFLD), cardiovascular diseases (CVD) and hepatocellular carcinoma (HCC). The causes for lipotoxicity are not only a high fat diet but also excessive lipolysis, adipogenesis and adipose tissue insulin resistance. The aims of this review are to investigate the subtle balances that underlie lipolytic, lipogenic and oxidative pathways, to evaluate critical points and the complexities of these processes and to better understand which are the metabolic derangements resulting from their imbalance, such as type 2 diabetes and non alcoholic fatty liver disease.
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spelling pubmed-46636032015-12-10 The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis Saponaro, Chiara Gaggini, Melania Carli, Fabrizia Gastaldelli, Amalia Nutrients Review Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, diabetes, fatty liver disease (NAFLD), cardiovascular diseases (CVD) and hepatocellular carcinoma (HCC). The causes for lipotoxicity are not only a high fat diet but also excessive lipolysis, adipogenesis and adipose tissue insulin resistance. The aims of this review are to investigate the subtle balances that underlie lipolytic, lipogenic and oxidative pathways, to evaluate critical points and the complexities of these processes and to better understand which are the metabolic derangements resulting from their imbalance, such as type 2 diabetes and non alcoholic fatty liver disease. MDPI 2015-11-13 /pmc/articles/PMC4663603/ /pubmed/26580649 http://dx.doi.org/10.3390/nu7115475 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saponaro, Chiara
Gaggini, Melania
Carli, Fabrizia
Gastaldelli, Amalia
The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
title The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
title_full The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
title_fullStr The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
title_full_unstemmed The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
title_short The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
title_sort subtle balance between lipolysis and lipogenesis: a critical point in metabolic homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663603/
https://www.ncbi.nlm.nih.gov/pubmed/26580649
http://dx.doi.org/10.3390/nu7115475
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