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The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis
Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, di...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663603/ https://www.ncbi.nlm.nih.gov/pubmed/26580649 http://dx.doi.org/10.3390/nu7115475 |
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author | Saponaro, Chiara Gaggini, Melania Carli, Fabrizia Gastaldelli, Amalia |
author_facet | Saponaro, Chiara Gaggini, Melania Carli, Fabrizia Gastaldelli, Amalia |
author_sort | Saponaro, Chiara |
collection | PubMed |
description | Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, diabetes, fatty liver disease (NAFLD), cardiovascular diseases (CVD) and hepatocellular carcinoma (HCC). The causes for lipotoxicity are not only a high fat diet but also excessive lipolysis, adipogenesis and adipose tissue insulin resistance. The aims of this review are to investigate the subtle balances that underlie lipolytic, lipogenic and oxidative pathways, to evaluate critical points and the complexities of these processes and to better understand which are the metabolic derangements resulting from their imbalance, such as type 2 diabetes and non alcoholic fatty liver disease. |
format | Online Article Text |
id | pubmed-4663603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46636032015-12-10 The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis Saponaro, Chiara Gaggini, Melania Carli, Fabrizia Gastaldelli, Amalia Nutrients Review Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. This is now a recognized risk factor for the development of metabolic disorders, such as obesity, diabetes, fatty liver disease (NAFLD), cardiovascular diseases (CVD) and hepatocellular carcinoma (HCC). The causes for lipotoxicity are not only a high fat diet but also excessive lipolysis, adipogenesis and adipose tissue insulin resistance. The aims of this review are to investigate the subtle balances that underlie lipolytic, lipogenic and oxidative pathways, to evaluate critical points and the complexities of these processes and to better understand which are the metabolic derangements resulting from their imbalance, such as type 2 diabetes and non alcoholic fatty liver disease. MDPI 2015-11-13 /pmc/articles/PMC4663603/ /pubmed/26580649 http://dx.doi.org/10.3390/nu7115475 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Saponaro, Chiara Gaggini, Melania Carli, Fabrizia Gastaldelli, Amalia The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis |
title | The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis |
title_full | The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis |
title_fullStr | The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis |
title_full_unstemmed | The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis |
title_short | The Subtle Balance between Lipolysis and Lipogenesis: A Critical Point in Metabolic Homeostasis |
title_sort | subtle balance between lipolysis and lipogenesis: a critical point in metabolic homeostasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663603/ https://www.ncbi.nlm.nih.gov/pubmed/26580649 http://dx.doi.org/10.3390/nu7115475 |
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