Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

L-Glutamine (Gln) functions physiologically to balance tissue requirements of carbon and nitrogen. It has been proposed that in cancer cells undergoing aerobic glycolysis, accelerated anabolism is sustained by Gln-derived carbons, which replenish the tricarboxylic acid (TCA) cycle (anaplerosis). How...

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Detalles Bibliográficos
Autores principales: Tardito, Saverio, Oudin, Anaïs, Ahmed, Shafiq U., Fack, Fred, Keunen, Olivier, Zheng, Liang, Miletic, Hrvoje, Sakariassen, Per Øystein, Weinstock, Adam, Wagner, Allon, Lindsay, Susan L., Hock, Andreas K., Barnett, Susan C., Ruppin, Eytan, Mørkve, Svein Harald, Lund-Johansen, Morten, Chalmers, Anthony J., Bjerkvig, Rolf, Niclou, Simone P., Gottlieb, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663685/
https://www.ncbi.nlm.nih.gov/pubmed/26595383
http://dx.doi.org/10.1038/ncb3272

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