Crystal structure of CobK reveals strand-swapping between Rossmann-fold domains and molecular basis of the reduced precorrin product trap

CobK catalyzes the essential reduction of the precorrin ring in the cobalamin biosynthetic pathway. The crystal structure of CobK reveals that the enzyme, despite not having the signature sequence, comprises two Rossmann fold domains which bind coenzyme and substrate respectively. The two parallel β...

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Detalles Bibliográficos
Autores principales: Gu, Shuang, Sushko, Oleksandr, Deery, Evelyne, Warren, Martin J., Pickersgill, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663756/
https://www.ncbi.nlm.nih.gov/pubmed/26616290
http://dx.doi.org/10.1038/srep16943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663756/
https://www.ncbi.nlm.nih.gov/pubmed/26616290
http://dx.doi.org/10.1038/srep16943

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