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Invasive gastric mucormycosis and cytomegalovirus infection in an ABO incompatible renal transplant recipient

Opportunistic infections are common in immunocompromised patients, such as solid organ transplant recipients. Both fungal and viral infections in posttransplant period increase morbidity and mortality. Cytomegalovirus (CMV) remains one of the most important pathogens. CMV disease may manifest as a n...

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Autores principales: Nandwani, A., Jha, P. K., Duggal, R., Kher, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663777/
https://www.ncbi.nlm.nih.gov/pubmed/26664215
http://dx.doi.org/10.4103/0971-4065.157428
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author Nandwani, A.
Jha, P. K.
Duggal, R.
Kher, V.
author_facet Nandwani, A.
Jha, P. K.
Duggal, R.
Kher, V.
author_sort Nandwani, A.
collection PubMed
description Opportunistic infections are common in immunocompromised patients, such as solid organ transplant recipients. Both fungal and viral infections in posttransplant period increase morbidity and mortality. Cytomegalovirus (CMV) remains one of the most important pathogens. CMV disease may manifest as a nonspecific febrile syndrome or tissue-invasive infections. Zygomycosis is a rare infection, usually presents in rhino-cerebral, pulmonary and disseminated forms; gastrointestinal (GI) tract being a rare site of involvement. Newer techniques for early diagnosis and efficient therapies are essential for a better outcome of the disease; however, mortality rate remains high despite aggressive therapy. We report a renal transplant recipient, who developed gastric mucormycosis along with tissue invasive CMV disease, within 4 weeks of renal transplant and was diagnosed on the basis of upper GI endoscopy and gastric biopsy. The patient succumbed to the infection in spite of gastrectomy, antifungal and antiviral therapy.
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spelling pubmed-46637772015-12-10 Invasive gastric mucormycosis and cytomegalovirus infection in an ABO incompatible renal transplant recipient Nandwani, A. Jha, P. K. Duggal, R. Kher, V. Indian J Nephrol Case Report Opportunistic infections are common in immunocompromised patients, such as solid organ transplant recipients. Both fungal and viral infections in posttransplant period increase morbidity and mortality. Cytomegalovirus (CMV) remains one of the most important pathogens. CMV disease may manifest as a nonspecific febrile syndrome or tissue-invasive infections. Zygomycosis is a rare infection, usually presents in rhino-cerebral, pulmonary and disseminated forms; gastrointestinal (GI) tract being a rare site of involvement. Newer techniques for early diagnosis and efficient therapies are essential for a better outcome of the disease; however, mortality rate remains high despite aggressive therapy. We report a renal transplant recipient, who developed gastric mucormycosis along with tissue invasive CMV disease, within 4 weeks of renal transplant and was diagnosed on the basis of upper GI endoscopy and gastric biopsy. The patient succumbed to the infection in spite of gastrectomy, antifungal and antiviral therapy. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4663777/ /pubmed/26664215 http://dx.doi.org/10.4103/0971-4065.157428 Text en Copyright: © Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Nandwani, A.
Jha, P. K.
Duggal, R.
Kher, V.
Invasive gastric mucormycosis and cytomegalovirus infection in an ABO incompatible renal transplant recipient
title Invasive gastric mucormycosis and cytomegalovirus infection in an ABO incompatible renal transplant recipient
title_full Invasive gastric mucormycosis and cytomegalovirus infection in an ABO incompatible renal transplant recipient
title_fullStr Invasive gastric mucormycosis and cytomegalovirus infection in an ABO incompatible renal transplant recipient
title_full_unstemmed Invasive gastric mucormycosis and cytomegalovirus infection in an ABO incompatible renal transplant recipient
title_short Invasive gastric mucormycosis and cytomegalovirus infection in an ABO incompatible renal transplant recipient
title_sort invasive gastric mucormycosis and cytomegalovirus infection in an abo incompatible renal transplant recipient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663777/
https://www.ncbi.nlm.nih.gov/pubmed/26664215
http://dx.doi.org/10.4103/0971-4065.157428
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