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Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema

Platelet-derived microparticles (PDMPs) and adiponectin play an important role in the development of atherothrombosis. We investigated the effect of febuxostat on circulating PDMP levels and adiponectin in hyperuricemic patients. Levels of PDMP and biomarkers were measured using an ELISA at baseline...

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Autores principales: Nishizawa, Tohru, Taniura, Takehito, Nomura, Shosaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams And Wilkins 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664023/
https://www.ncbi.nlm.nih.gov/pubmed/26164850
http://dx.doi.org/10.1097/MBC.0000000000000335
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author Nishizawa, Tohru
Taniura, Takehito
Nomura, Shosaku
author_facet Nishizawa, Tohru
Taniura, Takehito
Nomura, Shosaku
author_sort Nishizawa, Tohru
collection PubMed
description Platelet-derived microparticles (PDMPs) and adiponectin play an important role in the development of atherothrombosis. We investigated the effect of febuxostat on circulating PDMP levels and adiponectin in hyperuricemic patients. Levels of PDMP and biomarkers were measured using an ELISA at baseline and after 2 and 6 months of treatment. Plasma levels of PDMPs and biomarkers were higher, while those of adiponectin were lower in hyperuricemic patients than in normouricemic controls. Uric acid and interleukin (IL)-6 levels decreased significantly in hyperuricemic patients after 2 months of febuxostat treatment. However, PDMP and biomarkers decreased significantly in hyperuricemic patients after only 6 months of febuxostat treatment and adiponectin increased significantly. These results suggest that the effects of febuxostat for PDMPs seen may be the effect on xanthine oxidase but not the decrease of uric acid, and febuxostat may be beneficial for primary prevention of atherothrombosis in hyperuricemic patients.
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spelling pubmed-46640232015-12-08 Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema Nishizawa, Tohru Taniura, Takehito Nomura, Shosaku Blood Coagul Fibrinolysis Original Articles Platelet-derived microparticles (PDMPs) and adiponectin play an important role in the development of atherothrombosis. We investigated the effect of febuxostat on circulating PDMP levels and adiponectin in hyperuricemic patients. Levels of PDMP and biomarkers were measured using an ELISA at baseline and after 2 and 6 months of treatment. Plasma levels of PDMPs and biomarkers were higher, while those of adiponectin were lower in hyperuricemic patients than in normouricemic controls. Uric acid and interleukin (IL)-6 levels decreased significantly in hyperuricemic patients after 2 months of febuxostat treatment. However, PDMP and biomarkers decreased significantly in hyperuricemic patients after only 6 months of febuxostat treatment and adiponectin increased significantly. These results suggest that the effects of febuxostat for PDMPs seen may be the effect on xanthine oxidase but not the decrease of uric acid, and febuxostat may be beneficial for primary prevention of atherothrombosis in hyperuricemic patients. Lippincott Williams And Wilkins 2015-12 2015-09-24 /pmc/articles/PMC4664023/ /pubmed/26164850 http://dx.doi.org/10.1097/MBC.0000000000000335 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Original Articles
Nishizawa, Tohru
Taniura, Takehito
Nomura, Shosaku
Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema
title Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema
title_full Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema
title_fullStr Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema
title_full_unstemmed Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema
title_short Effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema
title_sort effects of febuxostat on platelet-derived microparticles and adiponectin in patients with hyperuricema
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664023/
https://www.ncbi.nlm.nih.gov/pubmed/26164850
http://dx.doi.org/10.1097/MBC.0000000000000335
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