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A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study

BACKGROUND: Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. We investigated whether fatty liver disease, as assessed by the fatty liver index, could predict the development of hypertension...

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Autores principales: Huh, Ji Hye, Ahn, Song Vogue, Koh, Sang Baek, Choi, Eunhee, Kim, Jang Young, Sung, Ki-Chul, Kim, Eung Ju, Park, Jeong Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664241/
https://www.ncbi.nlm.nih.gov/pubmed/26618774
http://dx.doi.org/10.1371/journal.pone.0143560
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author Huh, Ji Hye
Ahn, Song Vogue
Koh, Sang Baek
Choi, Eunhee
Kim, Jang Young
Sung, Ki-Chul
Kim, Eung Ju
Park, Jeong Bae
author_facet Huh, Ji Hye
Ahn, Song Vogue
Koh, Sang Baek
Choi, Eunhee
Kim, Jang Young
Sung, Ki-Chul
Kim, Eung Ju
Park, Jeong Bae
author_sort Huh, Ji Hye
collection PubMed
description BACKGROUND: Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. We investigated whether fatty liver disease, as assessed by the fatty liver index, could predict the development of hypertension independently of systemic insulin resistance, inflammatory status and adipokine levels. METHODS: Prospective cohort study of 1,521 adults (484 men and 1037 women) aged 40 to 70 years without baseline hypertension examined. An equation was used to calculate fatty liver index and classify patients as follows: fatty liver index <30, no non-alcoholic fatty liver disease; fatty liver index ≥60, non-alcoholic fatty liver disease; and 30≤ fatty liver index <60, intermediate fatty liver index. RESULTS: During an average of 2.6 years of follow-up, 153 subjects (10.06%) developed hypertension. Fatty liver index was positively associated with baseline blood pressure, homeostasis model assessment of insulin resistance, urinary albumin/creatinine excretion, and high sensitivity C-reactive protein. After adjustment for confounding factors, including markers of insulin resistance, systemic inflammation and adiponectin levels, the odds ratio [95% confidence interval] for the incident hypertension increased in a graded manner with fatty liver index (<30 vs. 30–59 vs. ≥60 = 1 vs. 1.83 [1.16~2.88] vs. 2.09 [1.08~4.055], respectively). CONCLUSIONS: Non-alcoholic fatty liver disease assessed by fatty liver index was an independent risk factor for hypertension. Our findings suggest that fatty liver index, a simple surrogate indicator of fatty liver disease, might be useful for identifying subjects at high risk for incident hypertension in clinical practice.
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spelling pubmed-46642412015-12-10 A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study Huh, Ji Hye Ahn, Song Vogue Koh, Sang Baek Choi, Eunhee Kim, Jang Young Sung, Ki-Chul Kim, Eung Ju Park, Jeong Bae PLoS One Research Article BACKGROUND: Although non-alcoholic fatty liver disease is the hepatic manifestation of metabolic syndrome, its influence on hypertension development is poorly understood. We investigated whether fatty liver disease, as assessed by the fatty liver index, could predict the development of hypertension independently of systemic insulin resistance, inflammatory status and adipokine levels. METHODS: Prospective cohort study of 1,521 adults (484 men and 1037 women) aged 40 to 70 years without baseline hypertension examined. An equation was used to calculate fatty liver index and classify patients as follows: fatty liver index <30, no non-alcoholic fatty liver disease; fatty liver index ≥60, non-alcoholic fatty liver disease; and 30≤ fatty liver index <60, intermediate fatty liver index. RESULTS: During an average of 2.6 years of follow-up, 153 subjects (10.06%) developed hypertension. Fatty liver index was positively associated with baseline blood pressure, homeostasis model assessment of insulin resistance, urinary albumin/creatinine excretion, and high sensitivity C-reactive protein. After adjustment for confounding factors, including markers of insulin resistance, systemic inflammation and adiponectin levels, the odds ratio [95% confidence interval] for the incident hypertension increased in a graded manner with fatty liver index (<30 vs. 30–59 vs. ≥60 = 1 vs. 1.83 [1.16~2.88] vs. 2.09 [1.08~4.055], respectively). CONCLUSIONS: Non-alcoholic fatty liver disease assessed by fatty liver index was an independent risk factor for hypertension. Our findings suggest that fatty liver index, a simple surrogate indicator of fatty liver disease, might be useful for identifying subjects at high risk for incident hypertension in clinical practice. Public Library of Science 2015-11-30 /pmc/articles/PMC4664241/ /pubmed/26618774 http://dx.doi.org/10.1371/journal.pone.0143560 Text en © 2015 Huh et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Huh, Ji Hye
Ahn, Song Vogue
Koh, Sang Baek
Choi, Eunhee
Kim, Jang Young
Sung, Ki-Chul
Kim, Eung Ju
Park, Jeong Bae
A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study
title A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study
title_full A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study
title_fullStr A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study
title_full_unstemmed A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study
title_short A Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study
title_sort prospective study of fatty liver index and incident hypertension: the koges-arirang study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664241/
https://www.ncbi.nlm.nih.gov/pubmed/26618774
http://dx.doi.org/10.1371/journal.pone.0143560
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