Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex

A central event in Alzheimer’s disease is the accumulation of amyloid β (Aβ) peptides generated by the proteolytic cleavage of the amyloid precursor protein (APP). APP overexpression leads to increased Aβ generation and Alzheimer’s disease in humans and altered neuronal migration and increased long...

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Detalles Bibliográficos
Autores principales: Crenshaw, Ezekiel, Leung, Brian P., Kwok, Chun Kit, Sharoni, Michal, Olson, Kalee, Sebastian, Neeraj P., Ansaloni, Sara, Schweitzer-Stenner, Reinhard, Akins, Michael R., Bevilacqua, Philip C., Saunders, Aleister J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664259/
https://www.ncbi.nlm.nih.gov/pubmed/26618502
http://dx.doi.org/10.1371/journal.pone.0143160

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