Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients

INTRODUCTION: Recent evidence suggests that GSK3 activity is chondroprotective in osteoarthritis (OA), but at the same time, its inactivation has been proposed as an anti-inflammatory therapeutic option. Here we evaluated the extent of GSK3β inactivation in vivo in OA knee cartilage and the molecula...

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Detalles Bibliográficos
Autores principales: Guidotti, Serena, Minguzzi, Manuela, Platano, Daniela, Cattini, Luca, Trisolino, Giovanni, Mariani, Erminia, Borzì, Rosa Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664288/
https://www.ncbi.nlm.nih.gov/pubmed/26618897
http://dx.doi.org/10.1371/journal.pone.0143865

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