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Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant

BACKGROUND: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant cul...

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Autores principales: Chajra, Hanane, Redziniak, Gérard, Auriol, Daniel, Schweikert, Kuno, Lefevre, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664441/
https://www.ncbi.nlm.nih.gov/pubmed/26648748
http://dx.doi.org/10.2147/CCID.S93364
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author Chajra, Hanane
Redziniak, Gérard
Auriol, Daniel
Schweikert, Kuno
Lefevre, Fabrice
author_facet Chajra, Hanane
Redziniak, Gérard
Auriol, Daniel
Schweikert, Kuno
Lefevre, Fabrice
author_sort Chajra, Hanane
collection PubMed
description BACKGROUND: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant culture models. METHODS: The double-blinded clinical study was done in comparison to a vehicle by the determination of objective color parameters thanks to recognized quantitative and qualitative analysis tools, including Chroma-Meter, VISIA-CR™, and SIAscope™. Determination of L* (brightness), a* and b* (green–red and blue–yellow chromaticity coordinates), individual typology angle, and C* (chroma) and h* (hue angle) parameters using a Chroma-Meter demonstrated that THBG is able to modify skin color while quantification of ultraviolet (UV) spots by VISIA-CR™ confirmed its photoprotective effect. The mechanism of action of THBG molecule was determined using explant skin culture model coupled to histological analysis (epidermis melanin content staining). RESULTS: We have demonstrated that THBG was able to modulate significantly several critical parameters involved in skin color control such as L* (brightness), a* (redness), individual typology angle (pigmentation), and hue angle (yellowness in this study), whereas no modification occurs on b* and C* parameters. We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition. We also confirmed that THBG molecule is not a sunscreen agent. CONCLUSION: This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.
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spelling pubmed-46644412015-12-08 Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant Chajra, Hanane Redziniak, Gérard Auriol, Daniel Schweikert, Kuno Lefevre, Fabrice Clin Cosmet Investig Dermatol Original Research BACKGROUND: 3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant culture models. METHODS: The double-blinded clinical study was done in comparison to a vehicle by the determination of objective color parameters thanks to recognized quantitative and qualitative analysis tools, including Chroma-Meter, VISIA-CR™, and SIAscope™. Determination of L* (brightness), a* and b* (green–red and blue–yellow chromaticity coordinates), individual typology angle, and C* (chroma) and h* (hue angle) parameters using a Chroma-Meter demonstrated that THBG is able to modify skin color while quantification of ultraviolet (UV) spots by VISIA-CR™ confirmed its photoprotective effect. The mechanism of action of THBG molecule was determined using explant skin culture model coupled to histological analysis (epidermis melanin content staining). RESULTS: We have demonstrated that THBG was able to modulate significantly several critical parameters involved in skin color control such as L* (brightness), a* (redness), individual typology angle (pigmentation), and hue angle (yellowness in this study), whereas no modification occurs on b* and C* parameters. We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition. We also confirmed that THBG molecule is not a sunscreen agent. CONCLUSION: This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness. Dove Medical Press 2015-11-25 /pmc/articles/PMC4664441/ /pubmed/26648748 http://dx.doi.org/10.2147/CCID.S93364 Text en © 2015 Chajra et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Chajra, Hanane
Redziniak, Gérard
Auriol, Daniel
Schweikert, Kuno
Lefevre, Fabrice
Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant
title Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant
title_full Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant
title_fullStr Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant
title_full_unstemmed Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant
title_short Trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant
title_sort trihydroxybenzoic acid glucoside as a global skin color modulator and photo-protectant
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664441/
https://www.ncbi.nlm.nih.gov/pubmed/26648748
http://dx.doi.org/10.2147/CCID.S93364
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