Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

Protein Kinase A (PKA) is the major receptor for the cyclic adenosine monophosphate (cAMP) secondary messenger in eukaryotes. cAMP binds to two tandem cAMP-binding domains (CBD-A and -B) within the regulatory subunit of PKA (R), unleashing the activity of the catalytic subunit (C). While CBD-A in RI...

Descripción completa

Detalles Bibliográficos
Autores principales: Akimoto, Madoka, McNicholl, Eric Tyler, Ramkissoon, Avinash, Moleschi, Kody, Taylor, Susan S., Melacini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664472/
https://www.ncbi.nlm.nih.gov/pubmed/26618408
http://dx.doi.org/10.1371/journal.pbio.1002305

Ejemplares similares

Ejemplares similares