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Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma

PURPOSE: To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma. PATIENTS AND METHODS: The subjects of the study were patients undergoing...

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Autores principales: Naito, Tomoko, Yoshikawa, Keiji, Mizoue, Shiro, Nanno, Mami, Kimura, Tairo, Suzumura, Hirotaka, Takeda, Ryuji, Shiraga, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664511/
https://www.ncbi.nlm.nih.gov/pubmed/26648689
http://dx.doi.org/10.2147/OPTH.S94497
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author Naito, Tomoko
Yoshikawa, Keiji
Mizoue, Shiro
Nanno, Mami
Kimura, Tairo
Suzumura, Hirotaka
Takeda, Ryuji
Shiraga, Fumio
author_facet Naito, Tomoko
Yoshikawa, Keiji
Mizoue, Shiro
Nanno, Mami
Kimura, Tairo
Suzumura, Hirotaka
Takeda, Ryuji
Shiraga, Fumio
author_sort Naito, Tomoko
collection PubMed
description PURPOSE: To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma. PATIENTS AND METHODS: The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program). The VF progression was defined by a significantly negative MD slope (MD slope worsening) at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed. RESULTS: A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%), while no significant progression was evident in 93 eyes of 93 patients (56.4%). There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran–Armitage trend test). A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224) and four (odds ratio: 3.6, P=0.0008) consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282). The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0.01). CONCLUSION: This retrospective study has shown that three or more consecutive deterioration of MD value might be a predictor to future significant MD slope worsening in OAG.
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spelling pubmed-46645112015-12-08 Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma Naito, Tomoko Yoshikawa, Keiji Mizoue, Shiro Nanno, Mami Kimura, Tairo Suzumura, Hirotaka Takeda, Ryuji Shiraga, Fumio Clin Ophthalmol Original Research PURPOSE: To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma. PATIENTS AND METHODS: The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program). The VF progression was defined by a significantly negative MD slope (MD slope worsening) at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed. RESULTS: A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%), while no significant progression was evident in 93 eyes of 93 patients (56.4%). There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran–Armitage trend test). A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224) and four (odds ratio: 3.6, P=0.0008) consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282). The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0.01). CONCLUSION: This retrospective study has shown that three or more consecutive deterioration of MD value might be a predictor to future significant MD slope worsening in OAG. Dove Medical Press 2015-11-26 /pmc/articles/PMC4664511/ /pubmed/26648689 http://dx.doi.org/10.2147/OPTH.S94497 Text en © 2015 Naito et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Naito, Tomoko
Yoshikawa, Keiji
Mizoue, Shiro
Nanno, Mami
Kimura, Tairo
Suzumura, Hirotaka
Takeda, Ryuji
Shiraga, Fumio
Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_full Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_fullStr Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_full_unstemmed Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_short Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
title_sort relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664511/
https://www.ncbi.nlm.nih.gov/pubmed/26648689
http://dx.doi.org/10.2147/OPTH.S94497
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