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Update on genetics and diabetic retinopathy
Clinical risk factors for diabetic retinopathy (DR), such as duration of disease and degree of glucose control, do not adequately predict disease progression in individual patients, suggesting the presence of a genetic component. Multiple smaller studies have investigated genotype–phenotype correlat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664538/ https://www.ncbi.nlm.nih.gov/pubmed/26648684 http://dx.doi.org/10.2147/OPTH.S94508 |
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author | Hampton, Blake M Schwartz, Stephen G Brantley, Milam A Flynn, Harry W |
author_facet | Hampton, Blake M Schwartz, Stephen G Brantley, Milam A Flynn, Harry W |
author_sort | Hampton, Blake M |
collection | PubMed |
description | Clinical risk factors for diabetic retinopathy (DR), such as duration of disease and degree of glucose control, do not adequately predict disease progression in individual patients, suggesting the presence of a genetic component. Multiple smaller studies have investigated genotype–phenotype correlations in genes encoding vascular endothelial growth factor, aldose reductase, the receptor for advanced glycation end products, and many others. In general, reported results have been conflicting, due to factors including small sample sizes, variations in study design, differences in clinical end points, and underlying genetic differences between study groups. At this time, there is no confirmed association with any risk allele reported. As we continue to collect data from additional studies, the role of genetics in DR may become more apparent. |
format | Online Article Text |
id | pubmed-4664538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-46645382015-12-08 Update on genetics and diabetic retinopathy Hampton, Blake M Schwartz, Stephen G Brantley, Milam A Flynn, Harry W Clin Ophthalmol Review Clinical risk factors for diabetic retinopathy (DR), such as duration of disease and degree of glucose control, do not adequately predict disease progression in individual patients, suggesting the presence of a genetic component. Multiple smaller studies have investigated genotype–phenotype correlations in genes encoding vascular endothelial growth factor, aldose reductase, the receptor for advanced glycation end products, and many others. In general, reported results have been conflicting, due to factors including small sample sizes, variations in study design, differences in clinical end points, and underlying genetic differences between study groups. At this time, there is no confirmed association with any risk allele reported. As we continue to collect data from additional studies, the role of genetics in DR may become more apparent. Dove Medical Press 2015-11-23 /pmc/articles/PMC4664538/ /pubmed/26648684 http://dx.doi.org/10.2147/OPTH.S94508 Text en © 2015 Hampton et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Hampton, Blake M Schwartz, Stephen G Brantley, Milam A Flynn, Harry W Update on genetics and diabetic retinopathy |
title | Update on genetics and diabetic retinopathy |
title_full | Update on genetics and diabetic retinopathy |
title_fullStr | Update on genetics and diabetic retinopathy |
title_full_unstemmed | Update on genetics and diabetic retinopathy |
title_short | Update on genetics and diabetic retinopathy |
title_sort | update on genetics and diabetic retinopathy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664538/ https://www.ncbi.nlm.nih.gov/pubmed/26648684 http://dx.doi.org/10.2147/OPTH.S94508 |
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