miRNA profiling in autism spectrum disorder in China

Autism spectrum disorder (ASD) is a clinically complex and heterogeneous disorder. It is characterized by impaired social abilities, disordered language, isolated areas of interest, and repetitive behaviors. Evidence suggested that the neuropathology of ASD is widely distributed, involving epigeneti...

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Detalles Bibliográficos
Autores principales: Huang, Fengzhen, Zhou, Tieqiao, Yao, Xiaoxi, Yi, Jiping, Zhou, Fei, long, Zhe, Hou, Xuan, Wang, Chunrong, Chen, Zhao, Jiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data in Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664689/
https://www.ncbi.nlm.nih.gov/pubmed/26697346
http://dx.doi.org/10.1016/j.gdata.2015.08.006
Descripción
Sumario:Autism spectrum disorder (ASD) is a clinically complex and heterogeneous disorder. It is characterized by impaired social abilities, disordered language, isolated areas of interest, and repetitive behaviors. Evidence suggested that the neuropathology of ASD is widely distributed, involving epigenetic regulation in the brain. MiRNAs are a group of endogenous non-coding RNAs that play a critical role in neurodevelopment, neuroplasticity, and other fundamental neurobiological processes. To study miRNA profiling in Autism spectrum disorder in China, we performed miRNA microarray followed quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Here, we describe detailed methods and analysis on these microarray data which has been deposited in Gene Expression Omnibus (GEO): GSE67979.

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