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Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP

People with Down syndrome (DS) virtually all develop intellectual disability (ID) of varying degree of severity, and also have a high risk of early Alzheimer's disease (AD). ID prior to the onset of dementia, and its relationship to the onset of dementia in DS is a complex phenomenon influenced...

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Detalles Bibliográficos
Autores principales: Nizetic, Dean, Chen, Christopher L., Hong, Wanjin, Koo, Edward H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664698/
https://www.ncbi.nlm.nih.gov/pubmed/26648852
http://dx.doi.org/10.3389/fnbeh.2015.00299