The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea

Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea. In this study, our results showed that the survival rate of the liver cancer with food restriction and diarrh...

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Autores principales: Sun, Baoguo, Chen, Yan, Xiang, Ting, Zhang, Lei, Chen, Zexiong, Zhang, Shijun, Zhou, Houming, Chen, Shuqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664790/
https://www.ncbi.nlm.nih.gov/pubmed/26665149
http://dx.doi.org/10.1155/2015/752850
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author Sun, Baoguo
Chen, Yan
Xiang, Ting
Zhang, Lei
Chen, Zexiong
Zhang, Shijun
Zhou, Houming
Chen, Shuqing
author_facet Sun, Baoguo
Chen, Yan
Xiang, Ting
Zhang, Lei
Chen, Zexiong
Zhang, Shijun
Zhou, Houming
Chen, Shuqing
author_sort Sun, Baoguo
collection PubMed
description Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea. In this study, our results showed that the survival rate of the liver cancer with food restriction and diarrhea (FRD-LC) rats was lower than the liver cancer (LC) rats, and the tumor volume of the FRD-LC rats was higher than the LC rats. It was also shown that the high dose of JPJD significantly improved the survival rate, weight, and organ weight when compared with FRD-LC-induced rats. Moreover, JPJD administration upregulated the mRNA and protein levels of ABCC2 and downregulated the mRNA and protein levels of OATP1B2 in liver tissues. However, opposite results were observed in the cancer tissues. In conclusion, the study indicated that the Chinese Medicine JPJD could contribute to the rats with liver cancer which were pretreated with food restriction and diarrhea by regulating the expression of ABCC2 and OATP1B2 in liver tissues and cancer tissues.
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spelling pubmed-46647902015-12-09 The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea Sun, Baoguo Chen, Yan Xiang, Ting Zhang, Lei Chen, Zexiong Zhang, Shijun Zhou, Houming Chen, Shuqing Biomed Res Int Research Article Traditional Chinese Medicine Jianpijiedu decoction (JPJD) could improve the general status of liver cancer patients in clinics, especially the symptoms of decreased food intake and diarrhea. In this study, our results showed that the survival rate of the liver cancer with food restriction and diarrhea (FRD-LC) rats was lower than the liver cancer (LC) rats, and the tumor volume of the FRD-LC rats was higher than the LC rats. It was also shown that the high dose of JPJD significantly improved the survival rate, weight, and organ weight when compared with FRD-LC-induced rats. Moreover, JPJD administration upregulated the mRNA and protein levels of ABCC2 and downregulated the mRNA and protein levels of OATP1B2 in liver tissues. However, opposite results were observed in the cancer tissues. In conclusion, the study indicated that the Chinese Medicine JPJD could contribute to the rats with liver cancer which were pretreated with food restriction and diarrhea by regulating the expression of ABCC2 and OATP1B2 in liver tissues and cancer tissues. Hindawi Publishing Corporation 2015 2015-11-17 /pmc/articles/PMC4664790/ /pubmed/26665149 http://dx.doi.org/10.1155/2015/752850 Text en Copyright © 2015 Baoguo Sun et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sun, Baoguo
Chen, Yan
Xiang, Ting
Zhang, Lei
Chen, Zexiong
Zhang, Shijun
Zhou, Houming
Chen, Shuqing
The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea
title The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea
title_full The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea
title_fullStr The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea
title_full_unstemmed The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea
title_short The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea
title_sort chinese herb jianpijiedu contributes to the regulation of oatp1b2 and abcc2 in a rat model of orthotopic transplantation liver cancer pretreated with food restriction and diarrhea
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664790/
https://www.ncbi.nlm.nih.gov/pubmed/26665149
http://dx.doi.org/10.1155/2015/752850
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