Cargando…

Expression of Ribonucleotide Reductase Subunit-2 and Thymidylate Synthase Correlates with Poor Prognosis in Patients with Resected Stages I–III Non-Small Cell Lung Cancer

Biomarkers can help to identify patients with early-stages or locally advanced non-small cell lung cancer (NSCLC) who have high risk of relapse and poor prognosis. To correlate the expression of seven biomarkers involved in DNA synthesis and repair and in cell division with clinical outcome, we cons...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grossi, Francesco, Dal Bello, Maria Giovanna, Salvi, Sandra, Puzone, Roberto, Pfeffer, Ulrich, Fontana, Vincenzo, Alama, Angela, Rijavec, Erika, Barletta, Giulia, Genova, Carlo, Sini, Claudio, Ratto, Giovanni Battista, Taviani, Mario, Truini, Mauro, Merlo, Domenico Franco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664813/ https://www.ncbi.nlm.nih.gov/pubmed/26663950 http://dx.doi.org/10.1155/2015/302649

Ejemplares similares

Glyceraldehyde-3-phosphate dehydrogenase gene over expression correlates with poor prognosis in non small cell lung cancer patients
por: Puzone, Roberto, et al.
Publicado: (2013)

Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase
por: Asuncion Valenzuela, Malyn M, et al.
Publicado: (2015)

Circulating Cell-Free DNA and Circulating Tumor Cells as Prognostic and Predictive Biomarkers in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Chemotherapy
por: Coco, Simona, et al.
Publicado: (2017)

Clinical Applications of Circulating Tumor Cells in Lung Cancer Patients by CellSearch System
por: Truini, Anna, et al.
Publicado: (2014)

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion
por: Mannava, Sudha, et al.
Publicado: (2012)

Next-Generation Sequencing Workflow for NSCLC Critical Samples Using a Targeted Sequencing Approach by Ion Torrent PGM™ Platform
por: Vanni, Irene, et al.
Publicado: (2015)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Whole exome sequencing of independent lung adenocarcinoma, lung squamous cell carcinoma, and malignant peritoneal mesothelioma: A case report
por: Vanni, Irene, et al.
Publicado: (2016)

Integrated Somatic and Germline Whole-Exome Sequencing Analysis in Women with Lung Cancer after a Previous Breast Cancer
por: Coco, Simona, et al.
Publicado: (2019)

Performance comparison of two commercial human whole-exome capture systems on formalin-fixed paraffin-embedded lung adenocarcinoma samples
por: Bonfiglio, Silvia, et al.
Publicado: (2016)

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity
por: Etienne, M-C, et al.
Publicado: (2004)

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis
por: Begley, Darren W., et al.
Publicado: (2011)

Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene
por: Tirakarn, Srisuda, et al.
Publicado: (2012)

Insights into the role of the junctional region of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase
por: Chaianantakul, Natpasit, et al.
Publicado: (2013)

Convergent allostery in ribonucleotide reductase
por: Thomas, William C., et al.
Publicado: (2019)

The periodic table of ribonucleotide reductases
por: Ruskoski, Terry B., et al.
Publicado: (2021)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

Downregulation of miR-99a/let-7c/miR-125b miRNA cluster predicts clinical outcome in patients with unresected malignant pleural mesothelioma
por: Truini, Anna, et al.
Publicado: (2017)

Chemical and genetic validation of dihydrofolate reductase–thymidylate synthase as a drug target in African trypanosomes
por: Sienkiewicz, Natasha, et al.
Publicado: (2008)

Phosphorylation of Thymidylate Synthase and Dihydrofolate Reductase in Cancer Cells and the Effect of CK2α Silencing
por: Wińska, Patrycja, et al.
Publicado: (2023)

The tyrosyl free radical in ribonucleotide reductase.
por: Gräslund, A, et al.
Publicado: (1985)

Serum proteomic test in advanced non-squamous non-small cell lung cancer treated in first line with standard chemotherapy
por: Grossi, F, et al.
Publicado: (2017)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

The bifunctional dihydrofolate reductase thymidylate synthase of Tetrahymena thermophila provides a tool for molecular and biotechnology applications
por: Herrmann, Lutz, et al.
Publicado: (2006)

Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases
por: Shamshad, Hina, et al.
Publicado: (2022)

Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species
por: Herrera-Acevedo, Chonny, et al.
Publicado: (2023)

Dual and selective inhibitors of pteridine reductase 1 (PTR1) and dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Leishmania chagasi
por: Teixeira, Bárbara Velame Ferreira, et al.
Publicado: (2019)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Rational polynomial representation of ribonucleotide reductase activity
por: Radivoyevitch, Tomas, et al.
Publicado: (2005)

Ribonucleotide reductases: essential enzymes for bacterial life
por: Torrents, Eduard
Publicado: (2014)

Functional Analysis of Plasmodium vivax Dihydrofolate Reductase-Thymidylate Synthase Genes through Stable Transformation of Plasmodium falciparum
por: Auliff, Alyson M., et al.
Publicado: (2012)

Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment
por: Lee, Won-Ja, et al.
Publicado: (2010)

Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure
por: Choi, Youngsok, et al.
Publicado: (2016)

The role of CEA, CYFRA21-1 and NSE in monitoring tumor response to Nivolumab in advanced non-small cell lung cancer (NSCLC) patients
por: Dal Bello, M. G., et al.
Publicado: (2019)

Correlation between B7-H4 and Survival of Non-Small-Cell Lung Cancer Patients Treated with Nivolumab
por: Genova, Carlo, et al.
Publicado: (2019)

Substrate Activation in Flavin-Dependent Thymidylate Synthase
por: Mishanina, Tatiana V., et al.
Publicado: (2014)

Concerted versus Stepwise Mechanism in Thymidylate Synthase
por: Islam, Zahidul, et al.
Publicado: (2014)

Hydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
por: Liew, Li Phing, et al.
Publicado: (2016)

Structural determinants and distribution of phosphate specificity in ribonucleotide reductases
por: Schell, Eugen, et al.
Publicado: (2021)

Ribonucleotide reductase, a novel drug target for gonorrhea
por: Narasimhan, Jana, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m9d4ve1c6n5tav6dv9irvmb6mk