Cargando…
The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy
This is a retrospective study of 51 consecutive hip reconstructions in children with cerebral palsy performed between 2011 and 2013. Tranexamic acid (TXA) was used in 14 hip reconstructions only. Transfusion rate was higher, postoperative Hb was lower, and patients stayed longer in the TXA group. Th...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664818/ https://www.ncbi.nlm.nih.gov/pubmed/26664830 http://dx.doi.org/10.1155/2015/827027 |
_version_ | 1782403494911672320 |
---|---|
author | Majid, I. Alshryda, S. Somanchi, B. Morakis, E. Foster, A. |
author_facet | Majid, I. Alshryda, S. Somanchi, B. Morakis, E. Foster, A. |
author_sort | Majid, I. |
collection | PubMed |
description | This is a retrospective study of 51 consecutive hip reconstructions in children with cerebral palsy performed between 2011 and 2013. Tranexamic acid (TXA) was used in 14 hip reconstructions only. Transfusion rate was higher, postoperative Hb was lower, and patients stayed longer in the TXA group. This did not reach a statistical significance (P = 0.75, 0.5, and 0.71, resp.). More than half of the patients who had TXA underwent bilateral hip reconstructions in comparison with 27% only in the non-TXA group. Bilateral hip reconstructions mean more surgery, more blood loss, and more blood transfusion. The patients who had TXA were significantly more disabled as evident by the higher proportions of patient with worse GMFCS levels. Although we have not been able to demonstrate the value of TXA in reducing blood loss and transfusion rate in children with CP who underwent hip reconstruction, it is hoped that an interest in exploring the value of TXA in paediatric orthopaedic surgery is generated. Ideally this should be explored further in an adequately powered, randomised controlled trial where risk of bias is minimized. |
format | Online Article Text |
id | pubmed-4664818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46648182015-12-09 The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy Majid, I. Alshryda, S. Somanchi, B. Morakis, E. Foster, A. J Blood Transfus Research Article This is a retrospective study of 51 consecutive hip reconstructions in children with cerebral palsy performed between 2011 and 2013. Tranexamic acid (TXA) was used in 14 hip reconstructions only. Transfusion rate was higher, postoperative Hb was lower, and patients stayed longer in the TXA group. This did not reach a statistical significance (P = 0.75, 0.5, and 0.71, resp.). More than half of the patients who had TXA underwent bilateral hip reconstructions in comparison with 27% only in the non-TXA group. Bilateral hip reconstructions mean more surgery, more blood loss, and more blood transfusion. The patients who had TXA were significantly more disabled as evident by the higher proportions of patient with worse GMFCS levels. Although we have not been able to demonstrate the value of TXA in reducing blood loss and transfusion rate in children with CP who underwent hip reconstruction, it is hoped that an interest in exploring the value of TXA in paediatric orthopaedic surgery is generated. Ideally this should be explored further in an adequately powered, randomised controlled trial where risk of bias is minimized. Hindawi Publishing Corporation 2015 2015-11-17 /pmc/articles/PMC4664818/ /pubmed/26664830 http://dx.doi.org/10.1155/2015/827027 Text en Copyright © 2015 I. Majid et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Majid, I. Alshryda, S. Somanchi, B. Morakis, E. Foster, A. The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy |
title | The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy |
title_full | The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy |
title_fullStr | The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy |
title_full_unstemmed | The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy |
title_short | The Value of Tranexamic Acid in Reducing Blood Loss following Hip Reconstruction in Children with Cerebral Palsy |
title_sort | value of tranexamic acid in reducing blood loss following hip reconstruction in children with cerebral palsy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664818/ https://www.ncbi.nlm.nih.gov/pubmed/26664830 http://dx.doi.org/10.1155/2015/827027 |
work_keys_str_mv | AT majidi thevalueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT alshrydas thevalueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT somanchib thevalueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT morakise thevalueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT fostera thevalueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT majidi valueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT alshrydas valueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT somanchib valueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT morakise valueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy AT fostera valueoftranexamicacidinreducingbloodlossfollowinghipreconstructioninchildrenwithcerebralpalsy |