Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work is to examine the molecular mechanisms and functional role...

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Detalles Bibliográficos
Autores principales: Jin, Lihua, Wang, Rui, Zhu, Yanlin, Zheng, Weili, Han, Yaping, Guo, Fusheng, Ye, Frank Bin, Li, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664883/
https://www.ncbi.nlm.nih.gov/pubmed/26620317
http://dx.doi.org/10.1038/srep17288

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