Neurodegenerative disease-associated mutants of a human mitochondrial aminoacyl-tRNA synthetase present individual molecular signatures

Mutations in human mitochondrial aminoacyl-tRNA synthetases are associated with a variety of neurodegenerative disorders. The effects of these mutations on the structure and function of the enzymes remain to be established. Here, we investigate six mutants of the aspartyl-tRNA synthetase correlated...

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Detalles Bibliográficos
Autores principales: Sauter, Claude, Lorber, Bernard, Gaudry, Agnès, Karim, Loukmane, Schwenzer, Hagen, Wien, Frank, Roblin, Pierre, Florentz, Catherine, Sissler, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664897/
https://www.ncbi.nlm.nih.gov/pubmed/26620921
http://dx.doi.org/10.1038/srep17332

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