Cargando…
Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy
To identify clinicopathologic and treatment variables that could predict pathologic tumor response to short-term neoadjuvant chemotherapy (NAC) for patients with locally advanced gastric cancer. A retrospective analysis was conducted of 178 patients who underwent short-term NAC with EOX regimen foll...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664910/ https://www.ncbi.nlm.nih.gov/pubmed/26620627 http://dx.doi.org/10.1038/srep17516 |
_version_ | 1782403510893019136 |
---|---|
author | Wu, Zhen-Feng Cao, Qin-Hong Wu, Xiao-Yu Chen, Che Xu, Zhe Li, Wei-Su Yao, Xue-Quan Liu, Fu-Kun |
author_facet | Wu, Zhen-Feng Cao, Qin-Hong Wu, Xiao-Yu Chen, Che Xu, Zhe Li, Wei-Su Yao, Xue-Quan Liu, Fu-Kun |
author_sort | Wu, Zhen-Feng |
collection | PubMed |
description | To identify clinicopathologic and treatment variables that could predict pathologic tumor response to short-term neoadjuvant chemotherapy (NAC) for patients with locally advanced gastric cancer. A retrospective analysis was conducted of 178 patients who underwent short-term NAC with EOX regimen followed by surgery from January 2008 to December 2010. Neoadjuvant treatment response was evaluated using tumor regression grade. Relationships between pathologic tumor response and clinicopathological factors were evaluated using logistic regression analysis. The benefits of regional arterial infusion chemotherapy were investigated separately. The postoperative pathological response rate was 46.1% (82/178) and 4 patients (2.2%) had complete pathological remission. Pathological response was significantly associated with tumor differentiation (P = 0.008), abnormal a-fetoprotein levels (P = 0.01) and administration approach to chemotherapy (intravenous versus regional arterial infusion chemotherapy) (P = 0.018). Most bone marrow toxicities, vomiting, nausea, alopecia, and fatigue were acceptable. Grade 3/4 toxicities were not commonly observed. The 3-year overall survival (OS) and recurrence free survival (RFS) were 67.0% and 53.0%, respectively. Regional arterial infusion NAC group had significantly better median RFS (48.0 versus 34.0 months) than the intravenous NAC group (P = 0.049). In conclusion, regional arterial infusion NAC can improve the pathological response rate of advanced gastric cancer treated with EOX regimen. |
format | Online Article Text |
id | pubmed-4664910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46649102015-12-03 Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy Wu, Zhen-Feng Cao, Qin-Hong Wu, Xiao-Yu Chen, Che Xu, Zhe Li, Wei-Su Yao, Xue-Quan Liu, Fu-Kun Sci Rep Article To identify clinicopathologic and treatment variables that could predict pathologic tumor response to short-term neoadjuvant chemotherapy (NAC) for patients with locally advanced gastric cancer. A retrospective analysis was conducted of 178 patients who underwent short-term NAC with EOX regimen followed by surgery from January 2008 to December 2010. Neoadjuvant treatment response was evaluated using tumor regression grade. Relationships between pathologic tumor response and clinicopathological factors were evaluated using logistic regression analysis. The benefits of regional arterial infusion chemotherapy were investigated separately. The postoperative pathological response rate was 46.1% (82/178) and 4 patients (2.2%) had complete pathological remission. Pathological response was significantly associated with tumor differentiation (P = 0.008), abnormal a-fetoprotein levels (P = 0.01) and administration approach to chemotherapy (intravenous versus regional arterial infusion chemotherapy) (P = 0.018). Most bone marrow toxicities, vomiting, nausea, alopecia, and fatigue were acceptable. Grade 3/4 toxicities were not commonly observed. The 3-year overall survival (OS) and recurrence free survival (RFS) were 67.0% and 53.0%, respectively. Regional arterial infusion NAC group had significantly better median RFS (48.0 versus 34.0 months) than the intravenous NAC group (P = 0.049). In conclusion, regional arterial infusion NAC can improve the pathological response rate of advanced gastric cancer treated with EOX regimen. Nature Publishing Group 2015-12-01 /pmc/articles/PMC4664910/ /pubmed/26620627 http://dx.doi.org/10.1038/srep17516 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Wu, Zhen-Feng Cao, Qin-Hong Wu, Xiao-Yu Chen, Che Xu, Zhe Li, Wei-Su Yao, Xue-Quan Liu, Fu-Kun Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy |
title | Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy |
title_full | Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy |
title_fullStr | Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy |
title_full_unstemmed | Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy |
title_short | Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy |
title_sort | regional arterial infusion chemotherapy improves the pathological response rate for advanced gastric cancer with short-term neoadjuvant chemotherapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664910/ https://www.ncbi.nlm.nih.gov/pubmed/26620627 http://dx.doi.org/10.1038/srep17516 |
work_keys_str_mv | AT wuzhenfeng regionalarterialinfusionchemotherapyimprovesthepathologicalresponserateforadvancedgastriccancerwithshorttermneoadjuvantchemotherapy AT caoqinhong regionalarterialinfusionchemotherapyimprovesthepathologicalresponserateforadvancedgastriccancerwithshorttermneoadjuvantchemotherapy AT wuxiaoyu regionalarterialinfusionchemotherapyimprovesthepathologicalresponserateforadvancedgastriccancerwithshorttermneoadjuvantchemotherapy AT chenche regionalarterialinfusionchemotherapyimprovesthepathologicalresponserateforadvancedgastriccancerwithshorttermneoadjuvantchemotherapy AT xuzhe regionalarterialinfusionchemotherapyimprovesthepathologicalresponserateforadvancedgastriccancerwithshorttermneoadjuvantchemotherapy AT liweisu regionalarterialinfusionchemotherapyimprovesthepathologicalresponserateforadvancedgastriccancerwithshorttermneoadjuvantchemotherapy AT yaoxuequan regionalarterialinfusionchemotherapyimprovesthepathologicalresponserateforadvancedgastriccancerwithshorttermneoadjuvantchemotherapy AT liufukun regionalarterialinfusionchemotherapyimprovesthepathologicalresponserateforadvancedgastriccancerwithshorttermneoadjuvantchemotherapy |