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The Impact of Wolbachia on Virus Infection in Mosquitoes

Mosquito-borne viruses such as dengue, West Nile and chikungunya viruses cause significant morbidity and mortality in human populations. Since current methods are not sufficient to control disease occurrence, novel methods to control transmission of arboviruses would be beneficial. Recent studies ha...

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Detalles Bibliográficos
Autor principal: Johnson, Karyn N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664976/
https://www.ncbi.nlm.nih.gov/pubmed/26556361
http://dx.doi.org/10.3390/v7112903
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author Johnson, Karyn N.
author_facet Johnson, Karyn N.
author_sort Johnson, Karyn N.
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description Mosquito-borne viruses such as dengue, West Nile and chikungunya viruses cause significant morbidity and mortality in human populations. Since current methods are not sufficient to control disease occurrence, novel methods to control transmission of arboviruses would be beneficial. Recent studies have shown that virus infection and transmission in insects can be impeded by co-infection with the bacterium Wolbachia pipientis. Wolbachia is a maternally inherited endosymbiont that is commonly found in insects, including a number of mosquito vector species. In Drosophila, Wolbachia mediates antiviral protection against a broad range of RNA viruses. This discovery pointed to a potential strategy to interfere with mosquito transmission of arboviruses by artificially infecting mosquitoes with Wolbachia. This review outlines research on the prevalence of Wolbachia in mosquito vector species and the impact of antiviral effects in both naturally and artificially Wolbachia-infected mosquitoes.
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spelling pubmed-46649762015-12-10 The Impact of Wolbachia on Virus Infection in Mosquitoes Johnson, Karyn N. Viruses Review Mosquito-borne viruses such as dengue, West Nile and chikungunya viruses cause significant morbidity and mortality in human populations. Since current methods are not sufficient to control disease occurrence, novel methods to control transmission of arboviruses would be beneficial. Recent studies have shown that virus infection and transmission in insects can be impeded by co-infection with the bacterium Wolbachia pipientis. Wolbachia is a maternally inherited endosymbiont that is commonly found in insects, including a number of mosquito vector species. In Drosophila, Wolbachia mediates antiviral protection against a broad range of RNA viruses. This discovery pointed to a potential strategy to interfere with mosquito transmission of arboviruses by artificially infecting mosquitoes with Wolbachia. This review outlines research on the prevalence of Wolbachia in mosquito vector species and the impact of antiviral effects in both naturally and artificially Wolbachia-infected mosquitoes. MDPI 2015-11-04 /pmc/articles/PMC4664976/ /pubmed/26556361 http://dx.doi.org/10.3390/v7112903 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Johnson, Karyn N.
The Impact of Wolbachia on Virus Infection in Mosquitoes
title The Impact of Wolbachia on Virus Infection in Mosquitoes
title_full The Impact of Wolbachia on Virus Infection in Mosquitoes
title_fullStr The Impact of Wolbachia on Virus Infection in Mosquitoes
title_full_unstemmed The Impact of Wolbachia on Virus Infection in Mosquitoes
title_short The Impact of Wolbachia on Virus Infection in Mosquitoes
title_sort impact of wolbachia on virus infection in mosquitoes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664976/
https://www.ncbi.nlm.nih.gov/pubmed/26556361
http://dx.doi.org/10.3390/v7112903
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