Chikungunya Virus Replication in Salivary Glands of the Mosquito Aedes albopictus

Chikungunya virus (CHIKV) is an emerging arbovirus transmitted to humans by mosquitoes such as Aedes albopictus. To be transmitted, CHIKV must replicate in the mosquito midgut, then disseminate in the hemocele and infect the salivary glands before being released in saliva. We have developed a standa...

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Detalles Bibliográficos
Autores principales: Vega-Rúa, Anubis, Schmitt, Christine, Bonne, Isabelle, Krijnse Locker, Jacomine, Failloux, Anna-Bella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664990/
https://www.ncbi.nlm.nih.gov/pubmed/26593936
http://dx.doi.org/10.3390/v7112917
Descripción
Sumario:Chikungunya virus (CHIKV) is an emerging arbovirus transmitted to humans by mosquitoes such as Aedes albopictus. To be transmitted, CHIKV must replicate in the mosquito midgut, then disseminate in the hemocele and infect the salivary glands before being released in saliva. We have developed a standardized protocol to visualize viral particles in the mosquito salivary glands using transmission electron microscopy. Here we provide direct evidence for CHIKV replication and storage in Ae. albopictus salivary glands.

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