Bacterial infection remodels the DNA methylation landscape of human dendritic cells

DNA methylation is an epigenetic mark thought to be robust to environmental perturbations on a short time scale. Here, we challenge that view by demonstrating that the infection of human dendritic cells (DCs) with a live pathogenic bacteria is associated with rapid and active demethylation at thousa...

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Detalles Bibliográficos
Autores principales: Pacis, Alain, Tailleux, Ludovic, Morin, Alexander M., Lambourne, John, MacIsaac, Julia L., Yotova, Vania, Dumaine, Anne, Danckaert, Anne, Luca, Francesca, Grenier, Jean-Christophe, Hansen, Kasper D., Gicquel, Brigitte, Yu, Miao, Pai, Athma, He, Chuan, Tung, Jenny, Pastinen, Tomi, Kobor, Michael S., Pique-Regi, Roger, Gilad, Yoav, Barreiro, Luis B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665002/
https://www.ncbi.nlm.nih.gov/pubmed/26392366
http://dx.doi.org/10.1101/gr.192005.115

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