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Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was dia...

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Autores principales: DONG, ZHE-YI, XING, HAI-TAO, WANG, YUAN-DA, ZHANG, WEI, QIU, QIANG, CHEN, XIANG-MEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665327/
https://www.ncbi.nlm.nih.gov/pubmed/26722248
http://dx.doi.org/10.3892/ol.2015.3669
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author DONG, ZHE-YI
XING, HAI-TAO
WANG, YUAN-DA
ZHANG, WEI
QIU, QIANG
CHEN, XIANG-MEI
author_facet DONG, ZHE-YI
XING, HAI-TAO
WANG, YUAN-DA
ZHANG, WEI
QIU, QIANG
CHEN, XIANG-MEI
author_sort DONG, ZHE-YI
collection PubMed
description The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was diagnosed by a renal biopsy performed for nephrotic syndrome (NS). The patient was admitted to the Chinese People's Liberation Army General Hospital one year later with a fever, anemia, unresolved NS and renal insufficiency. The patient was diagnosed with MM and a renal biopsy was repeated, the results of which suggested renal amyloidosis. The MM was treated with three cycles of vincristine, doxorubicin and dexamethasone chemotherapy. A review of the literature indicated that monoclonal gammopathy may lead to FSGS. It suggested that FSGS patients who are >40 years old should be routinely screened for plasma cell proliferative disorders to guide the treatment, determine a prognosis, achieve primary disease remission and avoid end-stage renal disease.
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spelling pubmed-46653272015-12-31 Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature DONG, ZHE-YI XING, HAI-TAO WANG, YUAN-DA ZHANG, WEI QIU, QIANG CHEN, XIANG-MEI Oncol Lett Articles The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was diagnosed by a renal biopsy performed for nephrotic syndrome (NS). The patient was admitted to the Chinese People's Liberation Army General Hospital one year later with a fever, anemia, unresolved NS and renal insufficiency. The patient was diagnosed with MM and a renal biopsy was repeated, the results of which suggested renal amyloidosis. The MM was treated with three cycles of vincristine, doxorubicin and dexamethasone chemotherapy. A review of the literature indicated that monoclonal gammopathy may lead to FSGS. It suggested that FSGS patients who are >40 years old should be routinely screened for plasma cell proliferative disorders to guide the treatment, determine a prognosis, achieve primary disease remission and avoid end-stage renal disease. D.A. Spandidos 2015-11 2015-09-03 /pmc/articles/PMC4665327/ /pubmed/26722248 http://dx.doi.org/10.3892/ol.2015.3669 Text en Copyright: © Dong et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
DONG, ZHE-YI
XING, HAI-TAO
WANG, YUAN-DA
ZHANG, WEI
QIU, QIANG
CHEN, XIANG-MEI
Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature
title Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature
title_full Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature
title_fullStr Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature
title_full_unstemmed Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature
title_short Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature
title_sort multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: a case report and review of the literature
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665327/
https://www.ncbi.nlm.nih.gov/pubmed/26722248
http://dx.doi.org/10.3892/ol.2015.3669
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