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Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature
The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was dia...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665327/ https://www.ncbi.nlm.nih.gov/pubmed/26722248 http://dx.doi.org/10.3892/ol.2015.3669 |
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author | DONG, ZHE-YI XING, HAI-TAO WANG, YUAN-DA ZHANG, WEI QIU, QIANG CHEN, XIANG-MEI |
author_facet | DONG, ZHE-YI XING, HAI-TAO WANG, YUAN-DA ZHANG, WEI QIU, QIANG CHEN, XIANG-MEI |
author_sort | DONG, ZHE-YI |
collection | PubMed |
description | The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was diagnosed by a renal biopsy performed for nephrotic syndrome (NS). The patient was admitted to the Chinese People's Liberation Army General Hospital one year later with a fever, anemia, unresolved NS and renal insufficiency. The patient was diagnosed with MM and a renal biopsy was repeated, the results of which suggested renal amyloidosis. The MM was treated with three cycles of vincristine, doxorubicin and dexamethasone chemotherapy. A review of the literature indicated that monoclonal gammopathy may lead to FSGS. It suggested that FSGS patients who are >40 years old should be routinely screened for plasma cell proliferative disorders to guide the treatment, determine a prognosis, achieve primary disease remission and avoid end-stage renal disease. |
format | Online Article Text |
id | pubmed-4665327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-46653272015-12-31 Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature DONG, ZHE-YI XING, HAI-TAO WANG, YUAN-DA ZHANG, WEI QIU, QIANG CHEN, XIANG-MEI Oncol Lett Articles The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was diagnosed by a renal biopsy performed for nephrotic syndrome (NS). The patient was admitted to the Chinese People's Liberation Army General Hospital one year later with a fever, anemia, unresolved NS and renal insufficiency. The patient was diagnosed with MM and a renal biopsy was repeated, the results of which suggested renal amyloidosis. The MM was treated with three cycles of vincristine, doxorubicin and dexamethasone chemotherapy. A review of the literature indicated that monoclonal gammopathy may lead to FSGS. It suggested that FSGS patients who are >40 years old should be routinely screened for plasma cell proliferative disorders to guide the treatment, determine a prognosis, achieve primary disease remission and avoid end-stage renal disease. D.A. Spandidos 2015-11 2015-09-03 /pmc/articles/PMC4665327/ /pubmed/26722248 http://dx.doi.org/10.3892/ol.2015.3669 Text en Copyright: © Dong et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles DONG, ZHE-YI XING, HAI-TAO WANG, YUAN-DA ZHANG, WEI QIU, QIANG CHEN, XIANG-MEI Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature |
title | Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature |
title_full | Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature |
title_fullStr | Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature |
title_full_unstemmed | Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature |
title_short | Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature |
title_sort | multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: a case report and review of the literature |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665327/ https://www.ncbi.nlm.nih.gov/pubmed/26722248 http://dx.doi.org/10.3892/ol.2015.3669 |
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