Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer...

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Autores principales: Zornhagen, Kamilla Westarp, Clausen, Malene M., Hansen, Anders E., Law, Ian, McEvoy, Fintan J., Engelholm, Svend A., Kjær, Andreas, Kristensen, Annemarie T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665600/
https://www.ncbi.nlm.nih.gov/pubmed/26854160
http://dx.doi.org/10.3390/diagnostics5030372
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author Zornhagen, Kamilla Westarp
Clausen, Malene M.
Hansen, Anders E.
Law, Ian
McEvoy, Fintan J.
Engelholm, Svend A.
Kjær, Andreas
Kristensen, Annemarie T.
author_facet Zornhagen, Kamilla Westarp
Clausen, Malene M.
Hansen, Anders E.
Law, Ian
McEvoy, Fintan J.
Engelholm, Svend A.
Kjær, Andreas
Kristensen, Annemarie T.
author_sort Zornhagen, Kamilla Westarp
collection PubMed
description Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using (18)F-FDG, (64)Cu-ATSM, and (18)F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in (18)F-FDG and (18)F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.
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spelling pubmed-46656002016-01-27 Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring Zornhagen, Kamilla Westarp Clausen, Malene M. Hansen, Anders E. Law, Ian McEvoy, Fintan J. Engelholm, Svend A. Kjær, Andreas Kristensen, Annemarie T. Diagnostics (Basel) Case Report Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using (18)F-FDG, (64)Cu-ATSM, and (18)F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in (18)F-FDG and (18)F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response. MDPI 2015-09-11 /pmc/articles/PMC4665600/ /pubmed/26854160 http://dx.doi.org/10.3390/diagnostics5030372 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Zornhagen, Kamilla Westarp
Clausen, Malene M.
Hansen, Anders E.
Law, Ian
McEvoy, Fintan J.
Engelholm, Svend A.
Kjær, Andreas
Kristensen, Annemarie T.
Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring
title Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring
title_full Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring
title_fullStr Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring
title_full_unstemmed Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring
title_short Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring
title_sort use of molecular imaging markers of glycolysis, hypoxia and proliferation ((18)f-fdg, (64)cu-atsm and (18)f-flt) in a dog with fibrosarcoma: the importance of individualized treatment planning and monitoring
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665600/
https://www.ncbi.nlm.nih.gov/pubmed/26854160
http://dx.doi.org/10.3390/diagnostics5030372
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