A rapid passage through a two-active-X-chromosome state accompanies the switch of imprinted X-inactivation patterns in mouse trophoblast stem cells

BACKGROUND: In female mice, while the presence of two-active X-chromosomes characterises pluripotency, it is not tolerated in most other cellular contexts. In particular, in the trophoblastic lineage, impairment of paternal X (X(P)) inactivation results in placental defects. RESULTS: Here, we show t...

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Detalles Bibliográficos
Autores principales: Prudhomme, Julie, Dubois, Agnès, Navarro, Pablo, Arnaud, Danielle, Avner, Philip, Morey, Céline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665903/
https://www.ncbi.nlm.nih.gov/pubmed/26628922
http://dx.doi.org/10.1186/s13072-015-0044-2

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