Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation

BACKGROUND: Precise spatiotemporal control of gene expression is essential for the establishment of correct cell numbers and identities during brain development. This process involves epigenetic control mechanisms, such as those mediated by the polycomb group protein Ezh2, which catalyzes trimethyla...

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Detalles Bibliográficos
Autores principales: Zemke, Martina, Draganova, Kalina, Klug, Annika, Schöler, Anne, Zurkirchen, Luis, Gay, Max Hans-Peter, Cheng, Phil, Koseki, Haruhiko, Valenta, Tomas, Schübeler, Dirk, Basler, Konrad, Sommer, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665911/
https://www.ncbi.nlm.nih.gov/pubmed/26621269
http://dx.doi.org/10.1186/s12915-015-0210-9

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