Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is characterized by progressive loss of midbrain dopaminergic neurons, resulting in motor dysfunctions. While most PD is sporadic in nature, a significant subset can be linked to either autosomal dominant or recessive mutations. PARK2, encoding the E3 ubiquitin l...

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Detalles Bibliográficos
Autores principales: Cha, Seon-Heui, Choi, Yu Ree, Heo, Cheol-Ho, Kang, Seo-Jun, Joe, Eun-Hye, Jou, Ilo, Kim, Hwan-Myung, Park, Sang Myun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666086/
https://www.ncbi.nlm.nih.gov/pubmed/26627850
http://dx.doi.org/10.1186/s13024-015-0060-5

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