Forty-five years of cell-cycle genetics

In the early 1970s, studies in Leland Hartwell’s laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps...

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Detalles Bibliográficos
Autores principales: Reid, Brian J., Culotti, Joseph G., Nash, Robert S., Pringle, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2015
Materias:
Retrospective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666127/
https://www.ncbi.nlm.nih.gov/pubmed/26628751
http://dx.doi.org/10.1091/mbc.E14-10-1484
Descripción
Sumario:In the early 1970s, studies in Leland Hartwell’s laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues.

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